Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis
Allergic conjunctivitis (AC) is one of the most common ocular disorders in clinical practice and is associated with meibomian gland dysfunction. This study aimed to explore the morphological and functional changes of meibomian glands (MGs) in pediatric and adult patients with AC and to analyze their...
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
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| author | Yuqing Wu Hao Jiang Xujiao Zhou Zimeng Zhai Pei Yang Shuyun Zhou Hao Gu Jianjiang Xu Jiaxu Hong |
| author_facet | Yuqing Wu Hao Jiang Xujiao Zhou Zimeng Zhai Pei Yang Shuyun Zhou Hao Gu Jianjiang Xu Jiaxu Hong |
| author_sort | Yuqing Wu |
| collection | DOAJ |
| description | Allergic conjunctivitis (AC) is one of the most common ocular disorders in clinical practice and is associated with meibomian gland dysfunction. This study aimed to explore the morphological and functional changes of meibomian glands (MGs) in pediatric and adult patients with AC and to analyze their potential predictors. In our prospective, observational cohort study, a total of 59 patients with AC were enrolled, with 30 patients aged ≤16 years in the pediatric group and 29 patients in the adult group. All patients underwent examinations at baseline and last visit when the complete resolution of conjunctival papillae was identified. An automatic MG analyzer was used to measure the morphological and functional parameters of MGs, including their area ratio (GA), tortuosity index (TI), and signal index (SI). Two groups were comparable at baseline in terms of characteristics and MG parameters (<i>p</i> > 0.05). The morphological (length, square, and GA) and functional MG parameters (SI) of AC patients significantly improved in the pediatric group after treatment (all <i>p</i> < 0.05), but not in the adult group. The change in the GA correlated with age, sex, GA, TI, and SI at baseline (all <i>p</i> < 0.05). Age (<i>p</i> = 0.001) and GA (<i>p</i> < 0.001) at baseline were predictors of an improvement in the GA of MGs. The findings showed that the structure and function of MGs in pediatric patients with AC seem to improve after the conjunctival papillae disappear, but not in adult patients. |
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| publishDate | 2022-03-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-7bc7f2c1bef346db85fc850d87d6d0d62023-11-23T23:15:45ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01115142710.3390/jcm11051427Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic ConjunctivitisYuqing Wu0Hao Jiang1Xujiao Zhou2Zimeng Zhai3Pei Yang4Shuyun Zhou5Hao Gu6Jianjiang Xu7Jiaxu Hong8Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, ChinaAllergic conjunctivitis (AC) is one of the most common ocular disorders in clinical practice and is associated with meibomian gland dysfunction. This study aimed to explore the morphological and functional changes of meibomian glands (MGs) in pediatric and adult patients with AC and to analyze their potential predictors. In our prospective, observational cohort study, a total of 59 patients with AC were enrolled, with 30 patients aged ≤16 years in the pediatric group and 29 patients in the adult group. All patients underwent examinations at baseline and last visit when the complete resolution of conjunctival papillae was identified. An automatic MG analyzer was used to measure the morphological and functional parameters of MGs, including their area ratio (GA), tortuosity index (TI), and signal index (SI). Two groups were comparable at baseline in terms of characteristics and MG parameters (<i>p</i> > 0.05). The morphological (length, square, and GA) and functional MG parameters (SI) of AC patients significantly improved in the pediatric group after treatment (all <i>p</i> < 0.05), but not in the adult group. The change in the GA correlated with age, sex, GA, TI, and SI at baseline (all <i>p</i> < 0.05). Age (<i>p</i> = 0.001) and GA (<i>p</i> < 0.001) at baseline were predictors of an improvement in the GA of MGs. The findings showed that the structure and function of MGs in pediatric patients with AC seem to improve after the conjunctival papillae disappear, but not in adult patients.https://www.mdpi.com/2077-0383/11/5/1427allergic conjunctivitismeibomian glandschilddry eyetear film |
| spellingShingle | Yuqing Wu Hao Jiang Xujiao Zhou Zimeng Zhai Pei Yang Shuyun Zhou Hao Gu Jianjiang Xu Jiaxu Hong Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis Journal of Clinical Medicine allergic conjunctivitis meibomian glands child dry eye tear film |
| title | Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis |
| title_full | Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis |
| title_fullStr | Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis |
| title_full_unstemmed | Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis |
| title_short | Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis |
| title_sort | morphological and functional changes of meibomian glands in pediatric and adult patients with allergic conjunctivitis |
| topic | allergic conjunctivitis meibomian glands child dry eye tear film |
| url | https://www.mdpi.com/2077-0383/11/5/1427 |
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