Thyroid function assessment in Saudi males with metabolic syndrome
Background: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=4;spage=352;epage=359;aulast=Aldhafiri |
| _version_ | 1811240520019607552 |
|---|---|
| author | Fahad Khalid Aldhafiri Fathy Elsayed Abdelgawad Gihan Mohamed Mohamed Bakri Tamer Saber |
| author_facet | Fahad Khalid Aldhafiri Fathy Elsayed Abdelgawad Gihan Mohamed Mohamed Bakri Tamer Saber |
| author_sort | Fahad Khalid Aldhafiri |
| collection | DOAJ |
| description | Background: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. Materials and Methods: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). Results: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. Conclusion: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD). |
| first_indexed | 2024-04-12T13:21:48Z |
| format | Article |
| id | doaj.art-7bca0d5e2a354b3ab231ea72ee7b7e88 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-04-12T13:21:48Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-7bca0d5e2a354b3ab231ea72ee7b7e882022-12-22T03:31:26ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062021-01-0113435235910.4103/jpbs.jpbs_745_21Thyroid function assessment in Saudi males with metabolic syndromeFahad Khalid AldhafiriFathy Elsayed AbdelgawadGihan Mohamed Mohamed BakriTamer SaberBackground: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. Materials and Methods: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). Results: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. Conclusion: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD).http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=4;spage=352;epage=359;aulast=Aldhafirimetabolic syndrome; thyroid and thyroid dysfunction; ldl/hdl cholesterol; obesity; hypertension; cardiovascular disease; lipids (tg) |
| spellingShingle | Fahad Khalid Aldhafiri Fathy Elsayed Abdelgawad Gihan Mohamed Mohamed Bakri Tamer Saber Thyroid function assessment in Saudi males with metabolic syndrome Journal of Pharmacy and Bioallied Sciences metabolic syndrome; thyroid and thyroid dysfunction; ldl/hdl cholesterol; obesity; hypertension; cardiovascular disease; lipids (tg) |
| title | Thyroid function assessment in Saudi males with metabolic syndrome |
| title_full | Thyroid function assessment in Saudi males with metabolic syndrome |
| title_fullStr | Thyroid function assessment in Saudi males with metabolic syndrome |
| title_full_unstemmed | Thyroid function assessment in Saudi males with metabolic syndrome |
| title_short | Thyroid function assessment in Saudi males with metabolic syndrome |
| title_sort | thyroid function assessment in saudi males with metabolic syndrome |
| topic | metabolic syndrome; thyroid and thyroid dysfunction; ldl/hdl cholesterol; obesity; hypertension; cardiovascular disease; lipids (tg) |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=4;spage=352;epage=359;aulast=Aldhafiri |
| work_keys_str_mv | AT fahadkhalidaldhafiri thyroidfunctionassessmentinsaudimaleswithmetabolicsyndrome AT fathyelsayedabdelgawad thyroidfunctionassessmentinsaudimaleswithmetabolicsyndrome AT gihanmohamedmohamedbakri thyroidfunctionassessmentinsaudimaleswithmetabolicsyndrome AT tamersaber thyroidfunctionassessmentinsaudimaleswithmetabolicsyndrome |