Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case report
Abstract Background Conjunctival myeloid sarcoma (MS) as an isolated presentation of acute myeloid leukemia (AML) relapse is rare. Here, we report a case of unilateral conjunctival MS revealed as a sign of AML relapse. Case presentation A 50-year-old man with a history of AML in remission visited ou...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-022-02286-1 |
| _version_ | 1819277024527646720 |
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| author | Joong Hyun Park Yengwoo Son Joon Young Hyon Ji Yun Lee Hyun Sun Jeon |
| author_facet | Joong Hyun Park Yengwoo Son Joon Young Hyon Ji Yun Lee Hyun Sun Jeon |
| author_sort | Joong Hyun Park |
| collection | DOAJ |
| description | Abstract Background Conjunctival myeloid sarcoma (MS) as an isolated presentation of acute myeloid leukemia (AML) relapse is rare. Here, we report a case of unilateral conjunctival MS revealed as a sign of AML relapse. Case presentation A 50-year-old man with a history of AML in remission visited our clinic presenting with a left conjunctival injection persisting for 1 month. Diffuse subconjunctival thickening with conjunctival vascular engorgement was observed. Ultrasound biomicroscopy revealed a hyper-reflective, thickened conjunctiva in his left eye. During the incisional biopsy, the lesion was strongly attached to the underlying sclera; histopathologic examination revealed infiltration of leukemic blasts. The relapse of AML was confirmed by a successive bone marrow biopsy. The ocular lesion disappeared after allogeneic peripheral blood stem cell transplantation (PBSCT) and concomitant salvage radiotherapy on the left eye. The patient has remained in remission for 3 years after allogeneic PBSCT. Conclusions Incidental conjunctival lesions can indicate AML relapse in patients treated earlier for AML. An ophthalmologist may have a role in the early detection of AML when a patient presents with an atypical conjunctival lesion. |
| first_indexed | 2024-12-23T23:49:32Z |
| format | Article |
| id | doaj.art-7bcaea2a2b63430ba5bbeef8d451f1a9 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-23T23:49:32Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-7bcaea2a2b63430ba5bbeef8d451f1a92022-12-21T17:25:26ZengBMCBMC Ophthalmology1471-24152022-02-012211610.1186/s12886-022-02286-1Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case reportJoong Hyun Park0Yengwoo Son1Joon Young Hyon2Ji Yun Lee3Hyun Sun Jeon4Department of Ophthalmology, Seoul National University Bundang HospitalDepartment of Ophthalmology, Seoul National University Bundang HospitalDepartment of Ophthalmology, Seoul National University Bundang HospitalDivision of Hematology-Oncology, Department of Internal Medicine, Seoul National University Bundang HospitalDepartment of Ophthalmology, Seoul National University Bundang HospitalAbstract Background Conjunctival myeloid sarcoma (MS) as an isolated presentation of acute myeloid leukemia (AML) relapse is rare. Here, we report a case of unilateral conjunctival MS revealed as a sign of AML relapse. Case presentation A 50-year-old man with a history of AML in remission visited our clinic presenting with a left conjunctival injection persisting for 1 month. Diffuse subconjunctival thickening with conjunctival vascular engorgement was observed. Ultrasound biomicroscopy revealed a hyper-reflective, thickened conjunctiva in his left eye. During the incisional biopsy, the lesion was strongly attached to the underlying sclera; histopathologic examination revealed infiltration of leukemic blasts. The relapse of AML was confirmed by a successive bone marrow biopsy. The ocular lesion disappeared after allogeneic peripheral blood stem cell transplantation (PBSCT) and concomitant salvage radiotherapy on the left eye. The patient has remained in remission for 3 years after allogeneic PBSCT. Conclusions Incidental conjunctival lesions can indicate AML relapse in patients treated earlier for AML. An ophthalmologist may have a role in the early detection of AML when a patient presents with an atypical conjunctival lesion.https://doi.org/10.1186/s12886-022-02286-1Acute myeloid leukemiaConjunctival myeloid sarcomaRadiotherapyRelapseCase report |
| spellingShingle | Joong Hyun Park Yengwoo Son Joon Young Hyon Ji Yun Lee Hyun Sun Jeon Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case report BMC Ophthalmology Acute myeloid leukemia Conjunctival myeloid sarcoma Radiotherapy Relapse Case report |
| title | Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case report |
| title_full | Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case report |
| title_fullStr | Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case report |
| title_full_unstemmed | Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case report |
| title_short | Relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma: a case report |
| title_sort | relapsed acute myeloid leukemia presenting as conjunctival myeloid sarcoma a case report |
| topic | Acute myeloid leukemia Conjunctival myeloid sarcoma Radiotherapy Relapse Case report |
| url | https://doi.org/10.1186/s12886-022-02286-1 |
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