Effect of Hydroxy Urea in treatment of patients with thalassemia Intermedia
Introduction: The β-thalassemia is one of the most common genetically transmitted blood disorders in the world. Sometimes Homozygote people demonstrate milder form of this disorder called intermedia. In this study, the effect of Hydroxy Urea (HU) was investigated in Thalassemia intermedia patients w...
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| Format: | Article |
| Language: | fas |
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Shahid Sadoughi University of Medical Sciences
2014-12-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| Subjects: | |
| Online Access: | http://jssu.ssu.ac.ir/browse.php?a_code=A-10-1542-1&slc_lang=en&sid=1 |
| _version_ | 1811267513901645824 |
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| author | A Fathi F Amani E Khoshbaf |
| author_facet | A Fathi F Amani E Khoshbaf |
| author_sort | A Fathi |
| collection | DOAJ |
| description | Introduction: The β-thalassemia is one of the most common genetically transmitted blood disorders in the world. Sometimes Homozygote people demonstrate milder form of this disorder called intermedia. In this study, the effect of Hydroxy Urea (HU) was investigated in Thalassemia intermedia patients who were treated monthly by packed cell transfusion as patients with major thalassemia in Bu-Ali Hospital of Ardebil.
Methods: This semi-experimental study consisted of 63 intermediate Thalassemia patients. All patients entered to study after completing inform consent and all transfusions were ceased and patients were treated by HU for 3and 6 months. All patients underwent CBC, Serum ferritin, liver and kidney function tests before starting HU and after 6 months of treatment. Moreover, at the end of 6 months, the patients’ transfusion need was evaluated. The test results were analyzed utilizing descriptive statistical methods (such as tables, graphs) and non-parametric Wilcoxon test via SPSS software (Version 18).
Results: After 6 months, 60 patients (95.2%) were completely needless of transfusion. In 3 patients (4.8%) transfusion interval prolonged more than one month. The study findings demonstrated a decrease in mean of ferritin level, and an increase in mean of hemoglobin level. Furthermore regarding the complications, AST, ALT, and BUN significantly increased after treatment with HU.
Conclusion: In thalassemia intermedia patients, HU can obviate the need for regular transfusion and increase the mean of Hb level. |
| first_indexed | 2024-04-12T21:03:51Z |
| format | Article |
| id | doaj.art-7bccbd38fa2545deb1b7085bd007c633 |
| institution | Directory Open Access Journal |
| issn | 2228-5741 2228-5733 |
| language | fas |
| last_indexed | 2024-04-12T21:03:51Z |
| publishDate | 2014-12-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj.art-7bccbd38fa2545deb1b7085bd007c6332022-12-22T03:16:47ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332014-12-0122514551463Effect of Hydroxy Urea in treatment of patients with thalassemia IntermediaA Fathi0F Amani1E Khoshbaf2 Ardabil University of Medical Sciences Ardabil University of Medical Sciences Ardabil University of Medical Sciences Introduction: The β-thalassemia is one of the most common genetically transmitted blood disorders in the world. Sometimes Homozygote people demonstrate milder form of this disorder called intermedia. In this study, the effect of Hydroxy Urea (HU) was investigated in Thalassemia intermedia patients who were treated monthly by packed cell transfusion as patients with major thalassemia in Bu-Ali Hospital of Ardebil. Methods: This semi-experimental study consisted of 63 intermediate Thalassemia patients. All patients entered to study after completing inform consent and all transfusions were ceased and patients were treated by HU for 3and 6 months. All patients underwent CBC, Serum ferritin, liver and kidney function tests before starting HU and after 6 months of treatment. Moreover, at the end of 6 months, the patients’ transfusion need was evaluated. The test results were analyzed utilizing descriptive statistical methods (such as tables, graphs) and non-parametric Wilcoxon test via SPSS software (Version 18). Results: After 6 months, 60 patients (95.2%) were completely needless of transfusion. In 3 patients (4.8%) transfusion interval prolonged more than one month. The study findings demonstrated a decrease in mean of ferritin level, and an increase in mean of hemoglobin level. Furthermore regarding the complications, AST, ALT, and BUN significantly increased after treatment with HU. Conclusion: In thalassemia intermedia patients, HU can obviate the need for regular transfusion and increase the mean of Hb level.http://jssu.ssu.ac.ir/browse.php?a_code=A-10-1542-1&slc_lang=en&sid=1Blood Transfusion Hemoglobin Hydroxy Urea Thalassemia Intermedia |
| spellingShingle | A Fathi F Amani E Khoshbaf Effect of Hydroxy Urea in treatment of patients with thalassemia Intermedia Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd Blood Transfusion Hemoglobin Hydroxy Urea Thalassemia Intermedia |
| title | Effect of Hydroxy Urea in treatment of patients with thalassemia Intermedia |
| title_full | Effect of Hydroxy Urea in treatment of patients with thalassemia Intermedia |
| title_fullStr | Effect of Hydroxy Urea in treatment of patients with thalassemia Intermedia |
| title_full_unstemmed | Effect of Hydroxy Urea in treatment of patients with thalassemia Intermedia |
| title_short | Effect of Hydroxy Urea in treatment of patients with thalassemia Intermedia |
| title_sort | effect of hydroxy urea in treatment of patients with thalassemia intermedia |
| topic | Blood Transfusion Hemoglobin Hydroxy Urea Thalassemia Intermedia |
| url | http://jssu.ssu.ac.ir/browse.php?a_code=A-10-1542-1&slc_lang=en&sid=1 |
| work_keys_str_mv | AT afathi effectofhydroxyureaintreatmentofpatientswiththalassemiaintermedia AT famani effectofhydroxyureaintreatmentofpatientswiththalassemiaintermedia AT ekhoshbaf effectofhydroxyureaintreatmentofpatientswiththalassemiaintermedia |