Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer
Known as a key effector in breast cancer (BC) progression, calcium (Ca<sup>2+</sup>) is tightly regulated to maintain the desired concentration to fine-tune cell functions. Ca<sup>2+</sup> channels are the main actors among Ca<sup>2+</sup> transporters that contro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/7/994 |
| _version_ | 1797411430702514176 |
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| author | Mohamed Chamlali Lise Rodat-Despoix Halima Ouadid-Ahidouch |
| author_facet | Mohamed Chamlali Lise Rodat-Despoix Halima Ouadid-Ahidouch |
| author_sort | Mohamed Chamlali |
| collection | DOAJ |
| description | Known as a key effector in breast cancer (BC) progression, calcium (Ca<sup>2+</sup>) is tightly regulated to maintain the desired concentration to fine-tune cell functions. Ca<sup>2+</sup> channels are the main actors among Ca<sup>2+</sup> transporters that control the intracellular Ca<sup>2+</sup> concentration in cells. It is well known that the basal Ca<sup>2+</sup> concentration is regulated by both store-dependent and independent Ca<sup>2+</sup> channels in BC development and progression. However, most of the literature has reported the role of store-dependent Ca<sup>2+</sup> entry, and only a few studies are focusing on store-independent Ca<sup>2+</sup> entry (SICE). In this review, we aim to summarize all findings on SICE in the BC progression field. |
| first_indexed | 2024-03-09T04:46:02Z |
| format | Article |
| id | doaj.art-7bcd198a097c40479197e76964d59bd4 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T04:46:02Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-7bcd198a097c40479197e76964d59bd42023-12-03T13:15:47ZengMDPI AGGenes2073-44252021-06-0112799410.3390/genes12070994Store-Independent Calcium Entry and Related Signaling Pathways in Breast CancerMohamed Chamlali0Lise Rodat-Despoix1Halima Ouadid-Ahidouch2Laboratory of Cellular and Molecular Physiology, UR-UPJV 4667, University of Picardie Jules Verne, 80000 Amiens, FranceLaboratory of Cellular and Molecular Physiology, UR-UPJV 4667, University of Picardie Jules Verne, 80000 Amiens, FranceLaboratory of Cellular and Molecular Physiology, UR-UPJV 4667, University of Picardie Jules Verne, 80000 Amiens, FranceKnown as a key effector in breast cancer (BC) progression, calcium (Ca<sup>2+</sup>) is tightly regulated to maintain the desired concentration to fine-tune cell functions. Ca<sup>2+</sup> channels are the main actors among Ca<sup>2+</sup> transporters that control the intracellular Ca<sup>2+</sup> concentration in cells. It is well known that the basal Ca<sup>2+</sup> concentration is regulated by both store-dependent and independent Ca<sup>2+</sup> channels in BC development and progression. However, most of the literature has reported the role of store-dependent Ca<sup>2+</sup> entry, and only a few studies are focusing on store-independent Ca<sup>2+</sup> entry (SICE). In this review, we aim to summarize all findings on SICE in the BC progression field.https://www.mdpi.com/2073-4425/12/7/994calcium channelsbasal calcium entryOrai-K<sup>+</sup> channel complextransient receptor potential channelsvoltage-gated calcium channelsbreast cancer |
| spellingShingle | Mohamed Chamlali Lise Rodat-Despoix Halima Ouadid-Ahidouch Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer Genes calcium channels basal calcium entry Orai-K<sup>+</sup> channel complex transient receptor potential channels voltage-gated calcium channels breast cancer |
| title | Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer |
| title_full | Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer |
| title_fullStr | Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer |
| title_full_unstemmed | Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer |
| title_short | Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer |
| title_sort | store independent calcium entry and related signaling pathways in breast cancer |
| topic | calcium channels basal calcium entry Orai-K<sup>+</sup> channel complex transient receptor potential channels voltage-gated calcium channels breast cancer |
| url | https://www.mdpi.com/2073-4425/12/7/994 |
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