HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population
Severe forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host's genetic predisposition to susceptibility or resistance to infe...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2012-03-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200012&lng=en&tlng=en |
| _version_ | 1797757123221782528 |
|---|---|
| author | Sérgio Pereira Monteiro Pedro Emmanuel Alvarenga Americano do Brasil Giselda Maria Kalil Cabello Rogério Valls de Souza Patrícia Brasil Ingebourg Georg Pedro Hernan Cabello Liane De Castro |
| author_facet | Sérgio Pereira Monteiro Pedro Emmanuel Alvarenga Americano do Brasil Giselda Maria Kalil Cabello Rogério Valls de Souza Patrícia Brasil Ingebourg Georg Pedro Hernan Cabello Liane De Castro |
| author_sort | Sérgio Pereira Monteiro |
| collection | DOAJ |
| description | Severe forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host's genetic predisposition to susceptibility or resistance to infectious diseases has been evidenced in several studies. The association of the human leukocyte antigen gene (HLA) class I alleles with DHF susceptibility or resistance has been reported in ethnically and geographically distinct populations. Due to these ethnic and viral strain differences, associations occur in each population, independently with a specific allele, which most likely explains the associations of several alleles with DHF. As the potential role of HLA alleles in the progression of DHF in Brazilian patients remains unknown, we then identified HLA-A alleles in 67 patients with dengue fever and 42 with DHF from Rio de Janeiro, Brazil, selected from 2002-2008 by the sequence-based typing technique. Statistical analysis revealed an association between the HLA-A*01 allele and DHF [odds ratio (OR) = 2.7, p = 0.01], while analysis of the HLA-A*31 allele (OR = 0.5, p = 0.11) suggested a potential protective role in DHF that should be further investigated. This study provides evidence that HLA class I alleles might be important risk factors for DHF in Brazilian patients. |
| first_indexed | 2024-03-12T18:10:25Z |
| format | Article |
| id | doaj.art-7bcd8a72d15a47a4b3bc74bbdfd0c37b |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:10:25Z |
| publishDate | 2012-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-7bcd8a72d15a47a4b3bc74bbdfd0c37b2023-08-02T09:15:49ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602012-03-01107222423010.1590/S0074-02762012000200012S0074-02762012000200012HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's populationSérgio Pereira Monteiro0Pedro Emmanuel Alvarenga Americano do Brasil1Giselda Maria Kalil Cabello2Rogério Valls de Souza3Patrícia Brasil4Ingebourg Georg5Pedro Hernan Cabello6Liane De Castro7Fundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzSevere forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host's genetic predisposition to susceptibility or resistance to infectious diseases has been evidenced in several studies. The association of the human leukocyte antigen gene (HLA) class I alleles with DHF susceptibility or resistance has been reported in ethnically and geographically distinct populations. Due to these ethnic and viral strain differences, associations occur in each population, independently with a specific allele, which most likely explains the associations of several alleles with DHF. As the potential role of HLA alleles in the progression of DHF in Brazilian patients remains unknown, we then identified HLA-A alleles in 67 patients with dengue fever and 42 with DHF from Rio de Janeiro, Brazil, selected from 2002-2008 by the sequence-based typing technique. Statistical analysis revealed an association between the HLA-A*01 allele and DHF [odds ratio (OR) = 2.7, p = 0.01], while analysis of the HLA-A*31 allele (OR = 0.5, p = 0.11) suggested a potential protective role in DHF that should be further investigated. This study provides evidence that HLA class I alleles might be important risk factors for DHF in Brazilian patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200012&lng=en&tlng=endengue feverdengue haemorrhagic feverHLA-AHLA typingBrazil |
| spellingShingle | Sérgio Pereira Monteiro Pedro Emmanuel Alvarenga Americano do Brasil Giselda Maria Kalil Cabello Rogério Valls de Souza Patrícia Brasil Ingebourg Georg Pedro Hernan Cabello Liane De Castro HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population Memorias do Instituto Oswaldo Cruz dengue fever dengue haemorrhagic fever HLA-A HLA typing Brazil |
| title | HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population |
| title_full | HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population |
| title_fullStr | HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population |
| title_full_unstemmed | HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population |
| title_short | HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population |
| title_sort | hla a 01 allele a risk factor for dengue haemorrhagic fever in brazil s population |
| topic | dengue fever dengue haemorrhagic fever HLA-A HLA typing Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200012&lng=en&tlng=en |
| work_keys_str_mv | AT sergiopereiramonteiro hlaa01alleleariskfactorfordenguehaemorrhagicfeverinbrazilspopulation AT pedroemmanuelalvarengaamericanodobrasil hlaa01alleleariskfactorfordenguehaemorrhagicfeverinbrazilspopulation AT giseldamariakalilcabello hlaa01alleleariskfactorfordenguehaemorrhagicfeverinbrazilspopulation AT rogeriovallsdesouza hlaa01alleleariskfactorfordenguehaemorrhagicfeverinbrazilspopulation AT patriciabrasil hlaa01alleleariskfactorfordenguehaemorrhagicfeverinbrazilspopulation AT ingebourggeorg hlaa01alleleariskfactorfordenguehaemorrhagicfeverinbrazilspopulation AT pedrohernancabello hlaa01alleleariskfactorfordenguehaemorrhagicfeverinbrazilspopulation AT lianedecastro hlaa01alleleariskfactorfordenguehaemorrhagicfeverinbrazilspopulation |