Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity
Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and prolifer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/10/1663 |
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| author | Leila Mohammadnezhad Mojtaba Shekarkar Azgomi Marco Pio La Manna Guido Sireci Chiara Rizzo Giusto Davide Badami Bartolo Tamburini Francesco Dieli Giuliana Guggino Nadia Caccamo |
| author_facet | Leila Mohammadnezhad Mojtaba Shekarkar Azgomi Marco Pio La Manna Guido Sireci Chiara Rizzo Giusto Davide Badami Bartolo Tamburini Francesco Dieli Giuliana Guggino Nadia Caccamo |
| author_sort | Leila Mohammadnezhad |
| collection | DOAJ |
| description | Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches. |
| first_indexed | 2024-03-10T03:10:42Z |
| format | Article |
| id | doaj.art-7bcf4f487caa45b6b54bc582ccb366fb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T03:10:42Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7bcf4f487caa45b6b54bc582ccb366fb2023-11-23T10:27:53ZengMDPI AGCells2073-44092022-05-011110166310.3390/cells11101663Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in AutoimmunityLeila Mohammadnezhad0Mojtaba Shekarkar Azgomi1Marco Pio La Manna2Guido Sireci3Chiara Rizzo4Giusto Davide Badami5Bartolo Tamburini6Francesco Dieli7Giuliana Guggino8Nadia Caccamo9Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, ItalyRheumatology Section, Internal Medicine and Medical Specialties, Department of Health Promotion, Mother and Child Care, University of Palermo, Piazza delle Cliniche 2, 90110 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, ItalyRheumatology Section, Internal Medicine and Medical Specialties, Department of Health Promotion, Mother and Child Care, University of Palermo, Piazza delle Cliniche 2, 90110 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), 90127 Palermo, ItalyImmune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches.https://www.mdpi.com/2073-4409/11/10/1663chronic inflammatory diseaseautoimmunityinnate immunityimmune responsetherapymetabolic pathways |
| spellingShingle | Leila Mohammadnezhad Mojtaba Shekarkar Azgomi Marco Pio La Manna Guido Sireci Chiara Rizzo Giusto Davide Badami Bartolo Tamburini Francesco Dieli Giuliana Guggino Nadia Caccamo Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity Cells chronic inflammatory disease autoimmunity innate immunity immune response therapy metabolic pathways |
| title | Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity |
| title_full | Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity |
| title_fullStr | Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity |
| title_full_unstemmed | Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity |
| title_short | Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity |
| title_sort | metabolic reprogramming of innate immune cells as a possible source of new therapeutic approaches in autoimmunity |
| topic | chronic inflammatory disease autoimmunity innate immunity immune response therapy metabolic pathways |
| url | https://www.mdpi.com/2073-4409/11/10/1663 |
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