Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium
Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.201902089 |
| _version_ | 1818154776889655296 |
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| author | Guomin Wang Wenjuan Jiang Shi Mo Lingxia Xie Qing Liao Liangsheng Hu Qingdong Ruan Kaiwei Tang Babak Mehrjou Mengting Liu Liping Tong Huaiyu Wang Jie Zhuang Guosong Wu Paul K. Chu |
| author_facet | Guomin Wang Wenjuan Jiang Shi Mo Lingxia Xie Qing Liao Liangsheng Hu Qingdong Ruan Kaiwei Tang Babak Mehrjou Mengting Liu Liping Tong Huaiyu Wang Jie Zhuang Guosong Wu Paul K. Chu |
| author_sort | Guomin Wang |
| collection | DOAJ |
| description | Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials. |
| first_indexed | 2024-12-11T14:31:53Z |
| format | Article |
| id | doaj.art-7bcf68770d834d96ba27b738d0e2c2ae |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-11T14:31:53Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-7bcf68770d834d96ba27b738d0e2c2ae2022-12-22T01:02:24ZengWileyAdvanced Science2198-38442020-01-0171n/an/a10.1002/advs.201902089Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on MagnesiumGuomin Wang0Wenjuan Jiang1Shi Mo2Lingxia Xie3Qing Liao4Liangsheng Hu5Qingdong Ruan6Kaiwei Tang7Babak Mehrjou8Mengting Liu9Liping Tong10Huaiyu Wang11Jie Zhuang12Guosong Wu13Paul K. Chu14Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong ChinaCollege of Pharmacy Western University of Health Sciences 309 E. Second St Pomona CA 91766 USADepartment of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong ChinaResearch Center for Biomedical Materials and Interfaces Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. ChinaResearch Center for Biomedical Materials and Interfaces Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. ChinaDepartment of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou University Guangdong 515063 P. R. ChinaDepartment of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong ChinaDepartment of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong ChinaDepartment of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong ChinaUSC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University of Southern California Los Angeles CA 90033 USAResearch Center for Biomedical Materials and Interfaces Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. ChinaResearch Center for Biomedical Materials and Interfaces Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. ChinaSuzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou 215163 P. R. ChinaCollege of Mechanics and Materials Hohai University Nanjing 211100 P. R. ChinaDepartment of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong ChinaAbstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials.https://doi.org/10.1002/advs.201902089antibacterialmagnesiumnanoflakenonleaching |
| spellingShingle | Guomin Wang Wenjuan Jiang Shi Mo Lingxia Xie Qing Liao Liangsheng Hu Qingdong Ruan Kaiwei Tang Babak Mehrjou Mengting Liu Liping Tong Huaiyu Wang Jie Zhuang Guosong Wu Paul K. Chu Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium Advanced Science antibacterial magnesium nanoflake nonleaching |
| title | Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium |
| title_full | Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium |
| title_fullStr | Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium |
| title_full_unstemmed | Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium |
| title_short | Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium |
| title_sort | nonleaching antibacterial concept demonstrated by in situ construction of 2d nanoflakes on magnesium |
| topic | antibacterial magnesium nanoflake nonleaching |
| url | https://doi.org/10.1002/advs.201902089 |
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