The Roles and Regulation of m<sup>6</sup>A Modification in Glioblastoma Stem Cells and Tumorigenesis
Glioblastoma is the most common and most lethal primary malignant brain tumor. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is a widespread and abundant internal messenger RNA (mRNA) modification found in eukaryotes. Accumulated evidence demonstrates that m<sup>6</...
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MDPI AG
2022-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/969 |
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| author | Peng Li Hope T. Richard Kezhou Zhu Linlin Li Suyun Huang |
| author_facet | Peng Li Hope T. Richard Kezhou Zhu Linlin Li Suyun Huang |
| author_sort | Peng Li |
| collection | DOAJ |
| description | Glioblastoma is the most common and most lethal primary malignant brain tumor. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is a widespread and abundant internal messenger RNA (mRNA) modification found in eukaryotes. Accumulated evidence demonstrates that m<sup>6</sup>A modification is aberrantly activated in human cancers and is critical for tumorigenesis and metastasis. m<sup>6</sup>A modification is also strongly involved in key signaling pathways and is associated with prognosis in glioblastoma. Here, we briefly outline the functions of m<sup>6</sup>A and its regulatory proteins, including m<sup>6</sup>A writers, erasers, and readers of the fate of RNA. We also summarize the latest breakthroughs in this field, describe the underlying molecular mechanisms that contribute to the tumorigenesis and progression, and highlight the inhibitors targeting the factors in m<sup>6</sup>A modification in glioblastoma. Further studies focusing on the specific pathways of m<sup>6</sup>A modification could help identify biomarkers and therapeutic targets that might prevent and treat glioblastoma. |
| first_indexed | 2024-03-10T03:18:31Z |
| format | Article |
| id | doaj.art-7bd0803762534ad1b7140e5c1bb6cb37 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:18:31Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7bd0803762534ad1b7140e5c1bb6cb372023-11-23T10:09:10ZengMDPI AGBiomedicines2227-90592022-04-0110596910.3390/biomedicines10050969The Roles and Regulation of m<sup>6</sup>A Modification in Glioblastoma Stem Cells and TumorigenesisPeng Li0Hope T. Richard1Kezhou Zhu2Linlin Li3Suyun Huang4Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Pathology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USAGlioblastoma is the most common and most lethal primary malignant brain tumor. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is a widespread and abundant internal messenger RNA (mRNA) modification found in eukaryotes. Accumulated evidence demonstrates that m<sup>6</sup>A modification is aberrantly activated in human cancers and is critical for tumorigenesis and metastasis. m<sup>6</sup>A modification is also strongly involved in key signaling pathways and is associated with prognosis in glioblastoma. Here, we briefly outline the functions of m<sup>6</sup>A and its regulatory proteins, including m<sup>6</sup>A writers, erasers, and readers of the fate of RNA. We also summarize the latest breakthroughs in this field, describe the underlying molecular mechanisms that contribute to the tumorigenesis and progression, and highlight the inhibitors targeting the factors in m<sup>6</sup>A modification in glioblastoma. Further studies focusing on the specific pathways of m<sup>6</sup>A modification could help identify biomarkers and therapeutic targets that might prevent and treat glioblastoma.https://www.mdpi.com/2227-9059/10/5/969m<sup>6</sup>A modificationglioblastomaepigeneticsmethyltransferasedemethylaseinhibitor |
| spellingShingle | Peng Li Hope T. Richard Kezhou Zhu Linlin Li Suyun Huang The Roles and Regulation of m<sup>6</sup>A Modification in Glioblastoma Stem Cells and Tumorigenesis Biomedicines m<sup>6</sup>A modification glioblastoma epigenetics methyltransferase demethylase inhibitor |
| title | The Roles and Regulation of m<sup>6</sup>A Modification in Glioblastoma Stem Cells and Tumorigenesis |
| title_full | The Roles and Regulation of m<sup>6</sup>A Modification in Glioblastoma Stem Cells and Tumorigenesis |
| title_fullStr | The Roles and Regulation of m<sup>6</sup>A Modification in Glioblastoma Stem Cells and Tumorigenesis |
| title_full_unstemmed | The Roles and Regulation of m<sup>6</sup>A Modification in Glioblastoma Stem Cells and Tumorigenesis |
| title_short | The Roles and Regulation of m<sup>6</sup>A Modification in Glioblastoma Stem Cells and Tumorigenesis |
| title_sort | roles and regulation of m sup 6 sup a modification in glioblastoma stem cells and tumorigenesis |
| topic | m<sup>6</sup>A modification glioblastoma epigenetics methyltransferase demethylase inhibitor |
| url | https://www.mdpi.com/2227-9059/10/5/969 |
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