Consequences of Shigella infection in young children: a systematic review
Objectives: We conducted a systematic review of the longitudinal consequences of Shigella infection in children to inform the value proposition for an effective vaccine. Methods: We searched PubMed and Embase for studies published from January 01, 1980 to December 12, 2022 and conducted in low- and...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223000346 |
| _version_ | 1797868290823946240 |
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| author | Tanya E. Libby Miranda L.M. Delawalla Fatima Al-Shimari Calman A. MacLennan Kirsten S. Vannice Patricia B. Pavlinac |
| author_facet | Tanya E. Libby Miranda L.M. Delawalla Fatima Al-Shimari Calman A. MacLennan Kirsten S. Vannice Patricia B. Pavlinac |
| author_sort | Tanya E. Libby |
| collection | DOAJ |
| description | Objectives: We conducted a systematic review of the longitudinal consequences of Shigella infection in children to inform the value proposition for an effective vaccine. Methods: We searched PubMed and Embase for studies published from January 01, 1980 to December 12, 2022 and conducted in low- and middle-income countries that included longitudinal follow-up after Shigella detection among children aged <5 years, irrespective of language. We collected data on all outcomes subsequent to Shigella detection, except mortality. Results: Of 2627 papers identified, 52 met inclusion criteria. The median sample size of children aged <5 years was 66 (range 5-2172). Data were collected in 20 countries; 56% (n = 29) of the publications included Bangladesh. The most common outcomes related to diarrhea (n = 20), linear growth (n = 14), and the mean total cost of a Shigella episode (n = 4; range: $ 6.22-31.10). Among children with Shigella diarrhea, 2.9-61.1% developed persistent diarrhea (≥14 days); the persistence was significantly more likely among children who were malnourished, had bloody stool, or had multidrug-resistant Shigella. Cumulative Shigella infections over the first 2 years of life contributed to the greatest loss in length-for-age z-score. Conclusion: We identified evidence that Shigella is associated with persistent diarrhea, linear growth faltering, and economic impact to the family. |
| first_indexed | 2024-04-09T23:54:43Z |
| format | Article |
| id | doaj.art-7bd16ee3e933434fb5a469f0616405fe |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-09T23:54:43Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-7bd16ee3e933434fb5a469f0616405fe2023-03-17T04:32:46ZengElsevierInternational Journal of Infectious Diseases1201-97122023-04-011297895Consequences of Shigella infection in young children: a systematic reviewTanya E. Libby0Miranda L.M. Delawalla1Fatima Al-Shimari2Calman A. MacLennan3Kirsten S. Vannice4Patricia B. Pavlinac5Department of Epidemiology, University of Washington, Seattle, Washington, USA; Corresponding author.Department of Epidemiology, University of Washington, Seattle, Washington, USADepartment of Global Health, University of Washington, Seattle, Washington, USABill and Melinda Gates Foundation, London, UKBill and Melinda Gates Foundation, Seattle, Washington, USADepartment of Global Health, University of Washington, Seattle, Washington, USAObjectives: We conducted a systematic review of the longitudinal consequences of Shigella infection in children to inform the value proposition for an effective vaccine. Methods: We searched PubMed and Embase for studies published from January 01, 1980 to December 12, 2022 and conducted in low- and middle-income countries that included longitudinal follow-up after Shigella detection among children aged <5 years, irrespective of language. We collected data on all outcomes subsequent to Shigella detection, except mortality. Results: Of 2627 papers identified, 52 met inclusion criteria. The median sample size of children aged <5 years was 66 (range 5-2172). Data were collected in 20 countries; 56% (n = 29) of the publications included Bangladesh. The most common outcomes related to diarrhea (n = 20), linear growth (n = 14), and the mean total cost of a Shigella episode (n = 4; range: $ 6.22-31.10). Among children with Shigella diarrhea, 2.9-61.1% developed persistent diarrhea (≥14 days); the persistence was significantly more likely among children who were malnourished, had bloody stool, or had multidrug-resistant Shigella. Cumulative Shigella infections over the first 2 years of life contributed to the greatest loss in length-for-age z-score. Conclusion: We identified evidence that Shigella is associated with persistent diarrhea, linear growth faltering, and economic impact to the family.http://www.sciencedirect.com/science/article/pii/S1201971223000346ShigellaStuntingEntericDiarrheaGrowth falteringVaccine |
| spellingShingle | Tanya E. Libby Miranda L.M. Delawalla Fatima Al-Shimari Calman A. MacLennan Kirsten S. Vannice Patricia B. Pavlinac Consequences of Shigella infection in young children: a systematic review International Journal of Infectious Diseases Shigella Stunting Enteric Diarrhea Growth faltering Vaccine |
| title | Consequences of Shigella infection in young children: a systematic review |
| title_full | Consequences of Shigella infection in young children: a systematic review |
| title_fullStr | Consequences of Shigella infection in young children: a systematic review |
| title_full_unstemmed | Consequences of Shigella infection in young children: a systematic review |
| title_short | Consequences of Shigella infection in young children: a systematic review |
| title_sort | consequences of shigella infection in young children a systematic review |
| topic | Shigella Stunting Enteric Diarrhea Growth faltering Vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223000346 |
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