The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study

Platelet-rich plasma (PRP) therapy holds substantial promise for the treatment of tennis elbow, a complex and challenging musculoskeletal condition. The aim of the study was to assess whether there are correlations between the levels of individual morphotic elements determined in whole blood and the...

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Main Authors: Karol Szyluk, Rostyslav Bubnov, Alicja Jarosz, Rafał Reguła, Piotr Grabowski, Joanna Iwanicka, Tomasz Iwanicki, Marcin Gierek, Dominik Sieroń, Andreas Christe, Paweł Niemiec
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Journal of Clinical Medicine
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Online Access:https://www.mdpi.com/2077-0383/13/1/77
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author Karol Szyluk
Rostyslav Bubnov
Alicja Jarosz
Rafał Reguła
Piotr Grabowski
Joanna Iwanicka
Tomasz Iwanicki
Marcin Gierek
Dominik Sieroń
Andreas Christe
Paweł Niemiec
author_facet Karol Szyluk
Rostyslav Bubnov
Alicja Jarosz
Rafał Reguła
Piotr Grabowski
Joanna Iwanicka
Tomasz Iwanicki
Marcin Gierek
Dominik Sieroń
Andreas Christe
Paweł Niemiec
author_sort Karol Szyluk
collection DOAJ
description Platelet-rich plasma (PRP) therapy holds substantial promise for the treatment of tennis elbow, a complex and challenging musculoskeletal condition. The aim of the study was to assess whether there are correlations between the levels of individual morphotic elements determined in whole blood and the outcomes of tennis elbow treatment with PRP injection, as measured using patient-reported outcome measures (PROMs) such as the Visual Analog Scale (VAS), Quick Disabilities of the Arm, Shoulder, and Hand (QDASH), and Patient-Rated Tennis Elbow Evaluation (PRTEE). A prospective analysis was conducted on 107 patients (132 elbows) undergoing lateral epicondylitis treatment with (PRP) injections. Patients completed VAS, PRTEE, and QDASH questionnaires on the day of PRP administration and at established checkpoints (2, 4, 8, 12, 24, 52, and 104 weeks). Minimal clinically important difference (MCID) was employed to assess the treatment effects. Then, correlations were measured within each PROM, and the impact of the concentration of individual blood parameters on the MCID outcomes was assessed. Analyzing the relationships between the MCID+ and MCID− groups, significant correlations for the VAS and QDASH scales were observed. The level of individual morphotic elements in the blood may have influenced the treatment outcome, as measured using specific patient-reported outcome measures (PROMs). Regarding the VAS scale, factors favoring a positive treatment outcome included higher values of eosinophils (EOS) and basophils (BASO). For the QDASH scale, these factors were a lower value of mean corpuscular volume (MCV) and a higher mean corpuscular hemoglobin (MCH). The levels of certain blood parameters, such as EOS and BASO, in the current study influenced the classification of patients into MCID+ or MCID− groups, based on the VAS and QDASH scales.
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spelling doaj.art-7bd22eec19024b4ab355f4d6ca5a04952024-01-10T15:00:56ZengMDPI AGJournal of Clinical Medicine2077-03832023-12-011317710.3390/jcm13010077The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective StudyKarol Szyluk0Rostyslav Bubnov1Alicja Jarosz2Rafał Reguła3Piotr Grabowski4Joanna Iwanicka5Tomasz Iwanicki6Marcin Gierek7Dominik Sieroń8Andreas Christe9Paweł Niemiec10Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandClinical Hospital “Pheophania” of State Affairs Department, Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 03143 Kyiv, UkraineDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandDistrict Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 Piekary Śląskie, PolandDistrict Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 Piekary Śląskie, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandCenter for Burns Treatment, Jana Pawła II Str., 41-100 Siemianowice Śląskie, PolandDepartment of Radiology SLS, Inselgroup, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, SwitzerlandDepartment of Radiology SLS, Inselgroup, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, SwitzerlandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandPlatelet-rich plasma (PRP) therapy holds substantial promise for the treatment of tennis elbow, a complex and challenging musculoskeletal condition. The aim of the study was to assess whether there are correlations between the levels of individual morphotic elements determined in whole blood and the outcomes of tennis elbow treatment with PRP injection, as measured using patient-reported outcome measures (PROMs) such as the Visual Analog Scale (VAS), Quick Disabilities of the Arm, Shoulder, and Hand (QDASH), and Patient-Rated Tennis Elbow Evaluation (PRTEE). A prospective analysis was conducted on 107 patients (132 elbows) undergoing lateral epicondylitis treatment with (PRP) injections. Patients completed VAS, PRTEE, and QDASH questionnaires on the day of PRP administration and at established checkpoints (2, 4, 8, 12, 24, 52, and 104 weeks). Minimal clinically important difference (MCID) was employed to assess the treatment effects. Then, correlations were measured within each PROM, and the impact of the concentration of individual blood parameters on the MCID outcomes was assessed. Analyzing the relationships between the MCID+ and MCID− groups, significant correlations for the VAS and QDASH scales were observed. The level of individual morphotic elements in the blood may have influenced the treatment outcome, as measured using specific patient-reported outcome measures (PROMs). Regarding the VAS scale, factors favoring a positive treatment outcome included higher values of eosinophils (EOS) and basophils (BASO). For the QDASH scale, these factors were a lower value of mean corpuscular volume (MCV) and a higher mean corpuscular hemoglobin (MCH). The levels of certain blood parameters, such as EOS and BASO, in the current study influenced the classification of patients into MCID+ or MCID− groups, based on the VAS and QDASH scales.https://www.mdpi.com/2077-0383/13/1/77tennis elbowlateral elbow tendinopathylateral epicondylitisplatelet-rich plasma (PRP)elbow pain
spellingShingle Karol Szyluk
Rostyslav Bubnov
Alicja Jarosz
Rafał Reguła
Piotr Grabowski
Joanna Iwanicka
Tomasz Iwanicki
Marcin Gierek
Dominik Sieroń
Andreas Christe
Paweł Niemiec
The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study
Journal of Clinical Medicine
tennis elbow
lateral elbow tendinopathy
lateral epicondylitis
platelet-rich plasma (PRP)
elbow pain
title The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study
title_full The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study
title_fullStr The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study
title_full_unstemmed The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study
title_short The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study
title_sort impact of blood morphological parameters on treatment outcomes in tennis elbow patients receiving platelet rich plasma prp therapy a prospective study
topic tennis elbow
lateral elbow tendinopathy
lateral epicondylitis
platelet-rich plasma (PRP)
elbow pain
url https://www.mdpi.com/2077-0383/13/1/77
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