Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Abstract Background WNT1 c.110 T>C and c.505G>T missense mutations have been identified in patients with osteogenesis imperfecta (OI). Whether these mutations affect osteoblast differentiation remains to be determined. This study aimed to investigate the effects of WNT1 c.110 T>C and c.505G...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang, Aijiao Ding
التنسيق: مقال
اللغة:English
منشور في: BMC 2021-06-01
سلاسل:Journal of Orthopaedic Surgery and Research
الموضوعات:
Osteogenesis imperfecta
Osteoblast
WNT1
Mutation
β-Catenin
الوصول للمادة أونلاين:https://doi.org/10.1186/s13018-021-02495-2

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