Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Abstract Background WNT1 c.110 T>C and c.505G>T missense mutations have been identified in patients with osteogenesis imperfecta (OI). Whether these mutations affect osteoblast differentiation remains to be determined. This study aimed to investigate the effects of WNT1 c.110 T>C and c.505G...

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Bibliographic Details
Main Authors: Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang, Aijiao Ding
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteogenesis imperfecta
Osteoblast
WNT1
Mutation
β-Catenin
Online Access:https://doi.org/10.1186/s13018-021-02495-2

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