Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Abstract Background WNT1 c.110 T>C and c.505G>T missense mutations have been identified in patients with osteogenesis imperfecta (OI). Whether these mutations affect osteoblast differentiation remains to be determined. This study aimed to investigate the effects of WNT1 c.110 T>C and c.505G...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang, Aijiao Ding
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: BMC 2021-06-01
Cyfres:Journal of Orthopaedic Surgery and Research
Pynciau:
Osteogenesis imperfecta
Osteoblast
WNT1
Mutation
β-Catenin
Mynediad Ar-lein:https://doi.org/10.1186/s13018-021-02495-2

Rhyngrwyd

https://doi.org/10.1186/s13018-021-02495-2

Eitemau Tebyg