Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Abstract Background WNT1 c.110 T>C and c.505G>T missense mutations have been identified in patients with osteogenesis imperfecta (OI). Whether these mutations affect osteoblast differentiation remains to be determined. This study aimed to investigate the effects of WNT1 c.110 T>C and c.505G...

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Detalles Bibliográficos
Autores principales: Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang, Aijiao Ding
Formato: Artículo
Lenguaje:English
Publicado: BMC 2021-06-01
Colección:Journal of Orthopaedic Surgery and Research
Materias:
Osteogenesis imperfecta
Osteoblast
WNT1
Mutation
β-Catenin
Acceso en línea:https://doi.org/10.1186/s13018-021-02495-2

Internet

https://doi.org/10.1186/s13018-021-02495-2

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