Evaluation of Total and Lipid Bound Sialic Acid in Serum in Oral Leukoplakia
Introduction: Oral cancer has become the most common cause of cancer related mortality which may be preceded by oral potentially malignant disorders. Altered glycosylation of glycoconjugates, such as sialic acid are one of the most important molecular changes accompanied during malignant transf...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9497/16483_CE[Ra]_F(Sh)_PF1(PrG_RK)_PFA(DK)_PF2(PrGGH).pdf |
| Summary: | Introduction: Oral cancer has become the most common
cause of cancer related mortality which may be preceded by
oral potentially malignant disorders. Altered glycosylation
of glycoconjugates, such as sialic acid are one of the most
important molecular changes accompanied during malignant
transformation in precancerous lesions like Oral Leukoplakia
(OL), and correlating them histopathologically with grades of
epithelial dysplasia which will serve clinical significance.
Aim: The aim of this study was to evaluate the significance of
serum Total Sialic Acid (TSA) and serum Lipid Bound Sialic Acid
(LSA) as a prognostic serum marker in Oral Leukoplakia.
Materials and Methods: Blood samples were collected from
30 patients diagnosed with OL and 30 healthy controls. Serum
sialic acid (total and lipid bound) levels were measured using
spectrophotometer. Tissue samples were histopathologically
typed and were graded for epithelial dysplasia. Data were
analysed using Independent t-test and Kruskal Wallis method.
Results: Serum levels of both total and lipid bound sialic acids
were found to be increased in OL when compared to healthy
controls.
The mean TSA levels among those in the OL group (45.3±4.2)
were significantly greater than healthy controls (29±2.2). On
multiple comparison the highest mean TSA level was found in
severe OL compared to moderate and mild OL (p<0.05). The
mean levels of LSA were found to be statistically non-significant
between the groups.
Conclusion: The present study showed that the serum levels
of both TSA and LSA were found to be increased in OL when
compared to apparently healthy controls. We also found that
with increasing grades of epithelial dysplasia TSA levels were
found to be gradually increasing which was significant for this
study serving as an early indicator for the detection of malignant
transformation in OL. |
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| ISSN: | 2249-782X 0973-709X |