Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China.
A total of 64 acute gastroenteritis outbreaks with 2,953 patients starting in December of 2016 and occurring mostly in the late spring of 2017 were reported in Jiangsu, China. A recombinant GII.P16-GII.2 norovirus variant was associated with 47 outbreaks (73.4%) for the gastroenteritis epidemic, pre...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5746213?pdf=render |
| _version_ | 1818289425791057920 |
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| author | Jian-Guang Fu Chao Shi Cheng Xu Qin Lin Jun Zhang Qian-Hua Yi Jun Zhang Chang-Jun Bao Xiang Huo Ye-Fei Zhu Jing Ai Zheng Xing |
| author_facet | Jian-Guang Fu Chao Shi Cheng Xu Qin Lin Jun Zhang Qian-Hua Yi Jun Zhang Chang-Jun Bao Xiang Huo Ye-Fei Zhu Jing Ai Zheng Xing |
| author_sort | Jian-Guang Fu |
| collection | DOAJ |
| description | A total of 64 acute gastroenteritis outbreaks with 2,953 patients starting in December of 2016 and occurring mostly in the late spring of 2017 were reported in Jiangsu, China. A recombinant GII.P16-GII.2 norovirus variant was associated with 47 outbreaks (73.4%) for the gastroenteritis epidemic, predominantly occurring in February and March of 2017. Sequence analysis of the RNA-dependent RNA polymerase (RdRp) and capsid protein of the viral isolates from these outbreaks confirmed that this GII.P16-GII.2 strain was the GII.P16-GII.2 variant with the intergenotypic recombination, identified in Taiwan, Hong Kong, and other cities in China in 2016. This GII.P16-GII.2 recombinant variant appeared to a re-emerging strain, firstly identified in 2011-2012 from Japan and USA but might be independently originated from other GII.P16-GII.2 variants for sporadic and outbreaks of gastroenteritis in Japan and China before 2016. Further identification of unique amino acid mutations in both VP1 and RdRp of NoV strain as shown in this report may provide insight in explaining its structural and antigenic changes, potentially critical for the variant recombinant to gain its predominance in causing regional and worldwide epidemics. |
| first_indexed | 2024-12-13T02:12:05Z |
| format | Article |
| id | doaj.art-7bd873137916427a9a8983a3000326a3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:12:05Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7bd873137916427a9a8983a3000326a32022-12-22T00:02:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011212e018609010.1371/journal.pone.0186090Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China.Jian-Guang FuChao ShiCheng XuQin LinJun ZhangQian-Hua YiJun ZhangChang-Jun BaoXiang HuoYe-Fei ZhuJing AiZheng XingA total of 64 acute gastroenteritis outbreaks with 2,953 patients starting in December of 2016 and occurring mostly in the late spring of 2017 were reported in Jiangsu, China. A recombinant GII.P16-GII.2 norovirus variant was associated with 47 outbreaks (73.4%) for the gastroenteritis epidemic, predominantly occurring in February and March of 2017. Sequence analysis of the RNA-dependent RNA polymerase (RdRp) and capsid protein of the viral isolates from these outbreaks confirmed that this GII.P16-GII.2 strain was the GII.P16-GII.2 variant with the intergenotypic recombination, identified in Taiwan, Hong Kong, and other cities in China in 2016. This GII.P16-GII.2 recombinant variant appeared to a re-emerging strain, firstly identified in 2011-2012 from Japan and USA but might be independently originated from other GII.P16-GII.2 variants for sporadic and outbreaks of gastroenteritis in Japan and China before 2016. Further identification of unique amino acid mutations in both VP1 and RdRp of NoV strain as shown in this report may provide insight in explaining its structural and antigenic changes, potentially critical for the variant recombinant to gain its predominance in causing regional and worldwide epidemics.http://europepmc.org/articles/PMC5746213?pdf=render |
| spellingShingle | Jian-Guang Fu Chao Shi Cheng Xu Qin Lin Jun Zhang Qian-Hua Yi Jun Zhang Chang-Jun Bao Xiang Huo Ye-Fei Zhu Jing Ai Zheng Xing Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China. PLoS ONE |
| title | Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China. |
| title_full | Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China. |
| title_fullStr | Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China. |
| title_full_unstemmed | Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China. |
| title_short | Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China. |
| title_sort | outbreaks of acute gastroenteritis associated with a re emerging gii p16 gii 2 norovirus in the spring of 2017 in jiangsu china |
| url | http://europepmc.org/articles/PMC5746213?pdf=render |
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