Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity
The in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown. Green synthesis of AgNPs is carried out by thermal treatment (80 and 90 °C) or UV irradiation of a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-07-01
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| Series: | Nanomaterials |
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| Online Access: | http://www.mdpi.com/2079-4991/6/8/137 |
| _version_ | 1818529741776355328 |
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| author | María Jesús Hortigüela Luis Yuste Fernando Rojo Inmaculada Aranaz |
| author_facet | María Jesús Hortigüela Luis Yuste Fernando Rojo Inmaculada Aranaz |
| author_sort | María Jesús Hortigüela |
| collection | DOAJ |
| description | The in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown. Green synthesis of AgNPs is carried out by thermal treatment (80 and 90 °C) or UV irradiation of a chondroitin sulfate solution containing AgNO3 without using any further reducing agents or stabilizers. Best control of the AgNPs size and polydispersity was achieved by UV irradiation. The ice-segregation-induced self-assembly (ISISA) process, in which the polymer solution containing the AgNPs is frozen unidirectionally, and successively freeze-drying were employed to produce the chondroitin sulfate 3D scaffolds. The scaffolds were further crosslinked with hexamethylene diisocyanate vapors to avoid water solubility of the 3D structures in aqueous environments. The antimicrobial activity of the scaffolds was tested against Escherichia coli. The minimum inhibitory concentration (MIC) found for AgNPs-CS (chondroitin sulfate) scaffolds was ca. 6 ppm. |
| first_indexed | 2024-12-11T17:10:49Z |
| format | Article |
| id | doaj.art-7bda10db590a4e8a846908c7c42c46b0 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-11T17:10:49Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-7bda10db590a4e8a846908c7c42c46b02022-12-22T00:57:32ZengMDPI AGNanomaterials2079-49912016-07-016813710.3390/nano6080137nano6080137Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial ActivityMaría Jesús Hortigüela0Luis Yuste1Fernando Rojo2Inmaculada Aranaz3Instituto de Ciencia de los Materiales, Consejo Superior de Investigaciones Científicas, Campus of Cantoblanco, Madrid 28049, SpainCentro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Campus of Cantoblanco, Madrid 28049, SpainCentro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Campus of Cantoblanco, Madrid 28049, SpainInstituto de Ciencia de los Materiales, Consejo Superior de Investigaciones Científicas, Campus of Cantoblanco, Madrid 28049, SpainThe in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown. Green synthesis of AgNPs is carried out by thermal treatment (80 and 90 °C) or UV irradiation of a chondroitin sulfate solution containing AgNO3 without using any further reducing agents or stabilizers. Best control of the AgNPs size and polydispersity was achieved by UV irradiation. The ice-segregation-induced self-assembly (ISISA) process, in which the polymer solution containing the AgNPs is frozen unidirectionally, and successively freeze-drying were employed to produce the chondroitin sulfate 3D scaffolds. The scaffolds were further crosslinked with hexamethylene diisocyanate vapors to avoid water solubility of the 3D structures in aqueous environments. The antimicrobial activity of the scaffolds was tested against Escherichia coli. The minimum inhibitory concentration (MIC) found for AgNPs-CS (chondroitin sulfate) scaffolds was ca. 6 ppm.http://www.mdpi.com/2079-4991/6/8/137chondroitin sulfatenanoparticlessilverscaffolds |
| spellingShingle | María Jesús Hortigüela Luis Yuste Fernando Rojo Inmaculada Aranaz Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity Nanomaterials chondroitin sulfate nanoparticles silver scaffolds |
| title | Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity |
| title_full | Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity |
| title_fullStr | Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity |
| title_full_unstemmed | Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity |
| title_short | Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity |
| title_sort | green synthesis of hierarchically structured silver polymer nanocomposites with antibacterial activity |
| topic | chondroitin sulfate nanoparticles silver scaffolds |
| url | http://www.mdpi.com/2079-4991/6/8/137 |
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