Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysis
BackgroundAnticoagulant treatment is used to treat and prevent venous thromboembolism (VTE). However, the relative effectiveness of newer anticoagulants vs. warfarin has not been appraised.ObjectiveThe aim was to evaluate the safety and efficacy of rivaroxaban for VTE in comparison to warfarin.Mater...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1086871/full |
| _version_ | 1827965910055387136 |
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| author | Zhuang Liu Dan Song Liang Wang Changfeng Wang Jie Zhou Jiali Sun Lei Guo |
| author_facet | Zhuang Liu Dan Song Liang Wang Changfeng Wang Jie Zhou Jiali Sun Lei Guo |
| author_sort | Zhuang Liu |
| collection | DOAJ |
| description | BackgroundAnticoagulant treatment is used to treat and prevent venous thromboembolism (VTE). However, the relative effectiveness of newer anticoagulants vs. warfarin has not been appraised.ObjectiveThe aim was to evaluate the safety and efficacy of rivaroxaban for VTE in comparison to warfarin.Materials and methodsFrom January 2000 until October 2021, all related studies were collected by EMBASE, the Cochrane Library, PubMed and Web of Scienceand. During the review process, two reviewers independently analyzed the included studies, including quality evaluation, screening and data extraction. We focused on VTE events as our primary outcomes.ResultsIn total, 20 trials were retrieved. These studies involved 230,320 patients, of which 74,018 received rivaroxaban and 156,302 received warfarin. Compared with warfarin, the incidence of VTE in rivaroxaban is significantly lower (risk ratio (RR) 0.71, 95% confidence interval (CI) [0.61, 0.84]; P < 0.0001, random effect model), and significantly reduced major [RR: 0.84, 95% CI (0.77, 0.91); P < 0.0001, fixed effect model] and nonmajor [RR: 0.55, 95% CI (0.41, 0.74); P < 0.0001, fixed effect model] bleeding. No significant differences in all-cause mortality between the two groups [RR: 0.68, 95% CI (0.45, 1.02); P = 0.06, fixed effect model].ConclusionRivaroxaban significantly reduced the incidence of VTE compared to warfarin in this meta-analysis. In order to verify these findings, larger sample sizes are required in well-designed studies. |
| first_indexed | 2024-04-09T17:40:44Z |
| format | Article |
| id | doaj.art-7bdc245eeb334a269c3059a150936dfe |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-09T17:40:44Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-7bdc245eeb334a269c3059a150936dfe2023-04-17T05:42:24ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-04-011010.3389/fsurg.2023.10868711086871Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysisZhuang LiuDan SongLiang WangChangfeng WangJie ZhouJiali SunLei GuoBackgroundAnticoagulant treatment is used to treat and prevent venous thromboembolism (VTE). However, the relative effectiveness of newer anticoagulants vs. warfarin has not been appraised.ObjectiveThe aim was to evaluate the safety and efficacy of rivaroxaban for VTE in comparison to warfarin.Materials and methodsFrom January 2000 until October 2021, all related studies were collected by EMBASE, the Cochrane Library, PubMed and Web of Scienceand. During the review process, two reviewers independently analyzed the included studies, including quality evaluation, screening and data extraction. We focused on VTE events as our primary outcomes.ResultsIn total, 20 trials were retrieved. These studies involved 230,320 patients, of which 74,018 received rivaroxaban and 156,302 received warfarin. Compared with warfarin, the incidence of VTE in rivaroxaban is significantly lower (risk ratio (RR) 0.71, 95% confidence interval (CI) [0.61, 0.84]; P < 0.0001, random effect model), and significantly reduced major [RR: 0.84, 95% CI (0.77, 0.91); P < 0.0001, fixed effect model] and nonmajor [RR: 0.55, 95% CI (0.41, 0.74); P < 0.0001, fixed effect model] bleeding. No significant differences in all-cause mortality between the two groups [RR: 0.68, 95% CI (0.45, 1.02); P = 0.06, fixed effect model].ConclusionRivaroxaban significantly reduced the incidence of VTE compared to warfarin in this meta-analysis. In order to verify these findings, larger sample sizes are required in well-designed studies.https://www.frontiersin.org/articles/10.3389/fsurg.2023.1086871/fullrivaroxabanvenous thromboembolismwarfarintreatmentprevetion |
| spellingShingle | Zhuang Liu Dan Song Liang Wang Changfeng Wang Jie Zhou Jiali Sun Lei Guo Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysis Frontiers in Surgery rivaroxaban venous thromboembolism warfarin treatment prevetion |
| title | Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysis |
| title_full | Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysis |
| title_fullStr | Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysis |
| title_full_unstemmed | Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysis |
| title_short | Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysis |
| title_sort | rivaroxaban vs warfarin for the treatment and prevention of venous thromboembolism a meta analysis |
| topic | rivaroxaban venous thromboembolism warfarin treatment prevetion |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1086871/full |
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