The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors
Salivary gland carcinomas (SGCs) represent a group of rare tumors, with complete surgical resection being the main treatment option. Therapeutic armory for cases of locally aggressive, recurrent, and/or metastatic SGCs, though, remains poor since they exhibit high rates of resistance to systematic t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9335 |
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| author | Despoina Pouloudi Aristoteles Sotiriadis Margarita Theodorakidou Panagiotis Sarantis Alexandros Pergaris Michalis V. Karamouzis Stamatios Theocharis |
| author_facet | Despoina Pouloudi Aristoteles Sotiriadis Margarita Theodorakidou Panagiotis Sarantis Alexandros Pergaris Michalis V. Karamouzis Stamatios Theocharis |
| author_sort | Despoina Pouloudi |
| collection | DOAJ |
| description | Salivary gland carcinomas (SGCs) represent a group of rare tumors, with complete surgical resection being the main treatment option. Therapeutic armory for cases of locally aggressive, recurrent, and/or metastatic SGCs, though, remains poor since they exhibit high rates of resistance to systematic therapy. Angiogenesis is considered one of the contemporary hallmarks of cancer and anti-angiogenic factors have already been approved for the treatment of several cancer types. This review aims to summarize, in a histotype-specific manner, the most current available data on the angiogenic factors implicated in SGC angiogenesis, in order to highlight the differences between the most common SGC histotypes and the factors that may have a potential role as therapeutic targets. |
| first_indexed | 2024-03-10T14:15:40Z |
| format | Article |
| id | doaj.art-7bdf8e0b83b34950ae1cb4bb472282a2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:15:40Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7bdf8e0b83b34950ae1cb4bb472282a22023-11-20T23:50:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124933510.3390/ijms21249335The Impact of Angiogenesis in the Most Common Salivary Gland Malignant TumorsDespoina Pouloudi0Aristoteles Sotiriadis1Margarita Theodorakidou2Panagiotis Sarantis3Alexandros Pergaris4Michalis V. Karamouzis5Stamatios Theocharis6First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceSalivary gland carcinomas (SGCs) represent a group of rare tumors, with complete surgical resection being the main treatment option. Therapeutic armory for cases of locally aggressive, recurrent, and/or metastatic SGCs, though, remains poor since they exhibit high rates of resistance to systematic therapy. Angiogenesis is considered one of the contemporary hallmarks of cancer and anti-angiogenic factors have already been approved for the treatment of several cancer types. This review aims to summarize, in a histotype-specific manner, the most current available data on the angiogenic factors implicated in SGC angiogenesis, in order to highlight the differences between the most common SGC histotypes and the factors that may have a potential role as therapeutic targets.https://www.mdpi.com/1422-0067/21/24/9335salivary gland tumorangiogenesisangiogenic factorsanti-angiogenic factorshistotypestherapy |
| spellingShingle | Despoina Pouloudi Aristoteles Sotiriadis Margarita Theodorakidou Panagiotis Sarantis Alexandros Pergaris Michalis V. Karamouzis Stamatios Theocharis The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors International Journal of Molecular Sciences salivary gland tumor angiogenesis angiogenic factors anti-angiogenic factors histotypes therapy |
| title | The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors |
| title_full | The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors |
| title_fullStr | The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors |
| title_full_unstemmed | The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors |
| title_short | The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors |
| title_sort | impact of angiogenesis in the most common salivary gland malignant tumors |
| topic | salivary gland tumor angiogenesis angiogenic factors anti-angiogenic factors histotypes therapy |
| url | https://www.mdpi.com/1422-0067/21/24/9335 |
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