Integrative model of genomic factors for determining binding site selection by estrogen receptor‐α

Integrative model of genomic factors for determining binding site selection by estrogen receptor‐α

A major question in transcription factor (TF) biology is why a TF binds to only a small fraction of motif eligible binding sites in the genome. Using the estrogen receptor‐α as a model system, we sought to explicitly define parameters that determine TF‐binding site selection. By examining 12 genetic...

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Bibliographic Details
Main Authors: Roy Joseph, Yuriy L Orlov, Mikael Huss, Wenjie Sun, Say Li Kong, Leena Ukil, You Fu Pan, Guoliang Li, Michael Lim, Jane S Thomsen, Yijun Ruan, Neil D Clarke, Shyam Prabhakar, Edwin Cheung, Edison T Liu
Format: Article
Language:English
Published: Springer Nature 2010-01-01
Series:Molecular Systems Biology
Subjects:
chromatin
DNA binding
modeling
recognition motifs
transcription factor
Online Access:https://doi.org/10.1038/msb.2010.109

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