Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng)
INTRODUCTION: It is now well accepted that inflammatory processes play a role in the etiopathogenesis of psychiatric disorders. NLRP3 inflammasome, which is formed by the combination of NLRP3, ASC and Caspase-1 proteins, and its activator NEK7, takes part in these processes. In this study, we aimed...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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ANP Publishing
2022-03-01
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| Series: | Klinik Psikiyatri Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=kpd&un=KPD-72687 |
| _version_ | 1797918633131769856 |
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| author | Melike Tetik Betül Önder Uzgan Cansu Aykaç Burcu Ekinci Tutku Yaraş Aykut Kuruoğlu Özge Akgül Tunç Alkın |
| author_facet | Melike Tetik Betül Önder Uzgan Cansu Aykaç Burcu Ekinci Tutku Yaraş Aykut Kuruoğlu Özge Akgül Tunç Alkın |
| author_sort | Melike Tetik |
| collection | DOAJ |
| description | INTRODUCTION: It is now well accepted that inflammatory processes play a role in the etiopathogenesis of psychiatric disorders. NLRP3 inflammasome, which is formed by the combination of NLRP3, ASC and Caspase-1 proteins, and its activator NEK7, takes part in these processes. In this study, we aimed to investigate the relationship between inflammatory markers (i.e. IL-1β, IL-18, NLRP3 inflammasome protein levels) and cognitive functions in patients with obsessive compulsive disorder (OCD). METHODS: Forty-two patients between the ages of 18-45 who were diagnosed with OCD were included in the study. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Hamilton Depression Scale (HAM-D) were used for clinical evaluations. In order to evaluate cognitive functions, Trail Making Test (TMT), Berg Card Sorting Test and Category Fluency Test were applied. IL-1β and IL-18 cytokine levels were determined by the ELISA method; measurement of the protein amounts of NLRP3, Caspase-1, ASC and NEK7 were performed by Western blotting. RESULTS: Serum IL-1β was negatively correlated with TMT (B-A) (rs=-.36, p= 0.019). Similarly, ASC was negatively correlated with TMT-B and TMT (B-A) (rs=-.38, p= 0.03; rs=-0.36, p = 0.04, respectively). However, no statistically significant relationship was found between other inflammatory parameters (NLRP3, Caspase-1, and IL-18) and neurocognitive tests. DISCUSSION AND CONCLUSION: Our results indicate that some aspects of neurocognitive impairment in patients with OCD might be related to neuroinflammatory processes, with implications for our understanding of the pathogenesis of OCD. |
| first_indexed | 2024-04-10T13:33:37Z |
| format | Article |
| id | doaj.art-7be2205be04a47618b9c962aa17e2902 |
| institution | Directory Open Access Journal |
| issn | 1302-0099 |
| language | English |
| last_indexed | 2024-04-10T13:33:37Z |
| publishDate | 2022-03-01 |
| publisher | ANP Publishing |
| record_format | Article |
| series | Klinik Psikiyatri Dergisi |
| spelling | doaj.art-7be2205be04a47618b9c962aa17e29022023-02-15T16:11:30ZengANP PublishingKlinik Psikiyatri Dergisi1302-00992022-03-01251758310.5505/kpd.2022.72687KPD-72687Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng)Melike Tetik0Betül Önder Uzgan1Cansu Aykaç2Burcu Ekinci3Tutku Yaraş4Aykut Kuruoğlu5Özge Akgül6Tunç Alkın7Department Of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, TurkeyDepartment Of Biology, Çanakkale Onsekiz Mart University Faculty Of Arts And Sciences, Çanakkale, TurkeyDepartment Of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, TurkeyIzmir International Biomedicine And Genome Institute, Dokuz Eylul University, Izmir, Turkey,Izmir International Biomedicine And Genome Institute, Dokuz Eylul University, Izmir, Turkey,Izmir Biomedicine and Genome Center, Izmir, TurkeyDepartment Of Psychology, İzmir Democracy University Faculty Of Arts And Sciences, İzmir, TurkeyDepartment Of Psychiatry, Dokuz Eylul University Faculty Of Medicine, Izmir, TurkeyINTRODUCTION: It is now well accepted that inflammatory processes play a role in the etiopathogenesis of psychiatric disorders. NLRP3 inflammasome, which is formed by the combination of NLRP3, ASC and Caspase-1 proteins, and its activator NEK7, takes part in these processes. In this study, we aimed to investigate the relationship between inflammatory markers (i.e. IL-1β, IL-18, NLRP3 inflammasome protein levels) and cognitive functions in patients with obsessive compulsive disorder (OCD). METHODS: Forty-two patients between the ages of 18-45 who were diagnosed with OCD were included in the study. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Hamilton Depression Scale (HAM-D) were used for clinical evaluations. In order to evaluate cognitive functions, Trail Making Test (TMT), Berg Card Sorting Test and Category Fluency Test were applied. IL-1β and IL-18 cytokine levels were determined by the ELISA method; measurement of the protein amounts of NLRP3, Caspase-1, ASC and NEK7 were performed by Western blotting. RESULTS: Serum IL-1β was negatively correlated with TMT (B-A) (rs=-.36, p= 0.019). Similarly, ASC was negatively correlated with TMT-B and TMT (B-A) (rs=-.38, p= 0.03; rs=-0.36, p = 0.04, respectively). However, no statistically significant relationship was found between other inflammatory parameters (NLRP3, Caspase-1, and IL-18) and neurocognitive tests. DISCUSSION AND CONCLUSION: Our results indicate that some aspects of neurocognitive impairment in patients with OCD might be related to neuroinflammatory processes, with implications for our understanding of the pathogenesis of OCD.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=kpd&un=KPD-72687ocdneuroinflammationnlrp3il-1betaneurocognition |
| spellingShingle | Melike Tetik Betül Önder Uzgan Cansu Aykaç Burcu Ekinci Tutku Yaraş Aykut Kuruoğlu Özge Akgül Tunç Alkın Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng) Klinik Psikiyatri Dergisi ocd neuroinflammation nlrp3 il-1beta neurocognition |
| title | Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng) |
| title_full | Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng) |
| title_fullStr | Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng) |
| title_full_unstemmed | Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng) |
| title_short | Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng) |
| title_sort | relation of asc and il 1beta with neurocognitive parameters in patients with obsessive compulsive disorder eng |
| topic | ocd neuroinflammation nlrp3 il-1beta neurocognition |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=kpd&un=KPD-72687 |
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