Induction of miR 21 impairs the anti-Leishmania response through inhibition of IL-12 in canine splenic leukocytes.

Induction of miR 21 impairs the anti-Leishmania response through inhibition of IL-12 in canine splenic leukocytes.

Visceral Leishmaniasis is a chronic zoonosis and, if left untreated, can be fatal. Infected dogs have decreased cellular immunity (Th1) and develop a potent humoral response (Th2), which is not effective for elimination of the protozoan. Immune response can be modulated by microRNAs (miRNAs), howeve...

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Bibliographic Details
Main Authors: Larissa Martins Melo, Jaqueline Poleto Bragato, Gabriela Lovizutto Venturin, Gabriela Torres Rebech, Sidnei Ferro Costa, Leandro Encarnação Garcia, Flávia Lombardi Lopes, Flávia de Rezende Eugênio, Paulo Sérgio Patto Dos Santos, Valéria Marçal Felix de Lima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0226192

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https://doi.org/10.1371/journal.pone.0226192

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