The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus
After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies. However, vaccines still represent an efficient...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/11/1844 |
| _version_ | 1827645361709121536 |
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| author | Jazmín García-Machorro Gema Lizbeth Ramírez-Salinas Marlet Martinez-Archundia José Correa-Basurto |
| author_facet | Jazmín García-Machorro Gema Lizbeth Ramírez-Salinas Marlet Martinez-Archundia José Correa-Basurto |
| author_sort | Jazmín García-Machorro |
| collection | DOAJ |
| description | After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies. However, vaccines still represent an efficient way to control the SARS-CoV-2 pandemic worldwide. This review describes the importance of bioinformatic and immunoinformatic tools (in silico) for guide vaccine design. In silico strategies permit the identification of epitopes (immunogenic peptides) which could be used as potential vaccines, as well as nonacarriers such as: vector viral based vaccines, RNA-based vaccines and dendrimers through immunoinformatics. Currently, nucleic acid and protein sequential as well structural analyses through bioinformatic tools allow us to get immunogenic epitopes which can induce immune response alone or in complex with nanocarriers. One of the advantages of in silico techniques is that they facilitate the identification of epitopes, while accelerating the process and helping to economize some stages of the development of safe vaccines. |
| first_indexed | 2024-03-09T18:34:17Z |
| format | Article |
| id | doaj.art-7be59b1bbe434ec487ebd794928e2a0b |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T18:34:17Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-7be59b1bbe434ec487ebd794928e2a0b2023-11-24T07:13:35ZengMDPI AGVaccines2076-393X2022-10-011011184410.3390/vaccines10111844The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for CoronavirusJazmín García-Machorro0Gema Lizbeth Ramírez-Salinas1Marlet Martinez-Archundia2José Correa-Basurto3Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoLaboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotécnológica, Escuela Superior de Medicina, Instituto Politécnico Nacional, México City 11340, MexicoLaboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotécnológica, Escuela Superior de Medicina, Instituto Politécnico Nacional, México City 11340, MexicoLaboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotécnológica, Escuela Superior de Medicina, Instituto Politécnico Nacional, México City 11340, MexicoAfter the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies. However, vaccines still represent an efficient way to control the SARS-CoV-2 pandemic worldwide. This review describes the importance of bioinformatic and immunoinformatic tools (in silico) for guide vaccine design. In silico strategies permit the identification of epitopes (immunogenic peptides) which could be used as potential vaccines, as well as nonacarriers such as: vector viral based vaccines, RNA-based vaccines and dendrimers through immunoinformatics. Currently, nucleic acid and protein sequential as well structural analyses through bioinformatic tools allow us to get immunogenic epitopes which can induce immune response alone or in complex with nanocarriers. One of the advantages of in silico techniques is that they facilitate the identification of epitopes, while accelerating the process and helping to economize some stages of the development of safe vaccines.https://www.mdpi.com/2076-393X/10/11/1844SARS-CoV-2COVID-19bioinformaticsimmunoinformaticsepitopevaccine |
| spellingShingle | Jazmín García-Machorro Gema Lizbeth Ramírez-Salinas Marlet Martinez-Archundia José Correa-Basurto The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus Vaccines SARS-CoV-2 COVID-19 bioinformatics immunoinformatics epitope vaccine |
| title | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
| title_full | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
| title_fullStr | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
| title_full_unstemmed | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
| title_short | The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus |
| title_sort | advantage of using immunoinformatic tools on vaccine design and development for coronavirus |
| topic | SARS-CoV-2 COVID-19 bioinformatics immunoinformatics epitope vaccine |
| url | https://www.mdpi.com/2076-393X/10/11/1844 |
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