Successful diagnosis and treatment of refractory peritonitis caused by Bacteroides thetaiotaomicron by high-throughput sequencing: a case report
Peritoneal dialysis-related peritonitis is a common complication of patients receiving peritoneal dialysis. However, peritonitis caused by anaerobic infection is rare. This article was reported a 44-year-old female patient who had undergone maintenance peritoneal dialysis for more than 4 years. She...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2022-06-01
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| Series: | Xin yixue |
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| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1658129473336-740502729.pdf |
| _version_ | 1797987421404528640 |
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| author | Lu Dongli, Liu Tonghuan, Wang Lixin, Lin Junjie |
| author_facet | Lu Dongli, Liu Tonghuan, Wang Lixin, Lin Junjie |
| author_sort | Lu Dongli, Liu Tonghuan, Wang Lixin, Lin Junjie |
| collection | DOAJ |
| description | Peritoneal dialysis-related peritonitis is a common complication of patients receiving peritoneal dialysis. However, peritonitis caused by anaerobic infection is rare. This article was reported a 44-year-old female patient who had undergone maintenance peritoneal dialysis for more than 4 years. She was admitted due to abdominal pain, diarrhea, and turbid peritoneal fluid after being diagnosed with peritoneal dialysis-related peritonitis. Repeated peritoneal fluid culture tests yielded negative results. After ineffective anti-infection treatment, the possibility of peritoneal dialysis-related refractory peritonitis was considered. Metagenomic next-generation sequencing （mNGS） pathogenic examination revealed the presence of Bacteroides thetaiotaomicron infection. She was recovered and discharged after combined use of metronidazole combined with imipenem and cilastatin sodium for 18 d. No recurrence of peritonitis was observed during follow-up. The diagnosis and treatment of this case prompt that attention should be paid to peritoneal dialysis-related peritonitis caused by anaerobic bacterial infection. mNGS can be applied in the routine examination of peritoneal dialysis-related peritonitis, aiming to improve the detection rate of pathogenic microorganisms, promptly select appropriate antibiotics for anti-infection therapy and enhance clinical prognosis of patients. |
| first_indexed | 2024-04-11T07:47:15Z |
| format | Article |
| id | doaj.art-7be6fb14beb24ac0bc4ddaeafd2b0d3b |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-11T07:47:15Z |
| publishDate | 2022-06-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-7be6fb14beb24ac0bc4ddaeafd2b0d3b2022-12-22T04:36:14ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022022-06-0153645345610.3969/j.issn.0253-9802.2022.06.013Successful diagnosis and treatment of refractory peritonitis caused by Bacteroides thetaiotaomicron by high-throughput sequencing: a case reportLu Dongli, Liu Tonghuan, Wang Lixin, Lin Junjie0△The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaPeritoneal dialysis-related peritonitis is a common complication of patients receiving peritoneal dialysis. However, peritonitis caused by anaerobic infection is rare. This article was reported a 44-year-old female patient who had undergone maintenance peritoneal dialysis for more than 4 years. She was admitted due to abdominal pain, diarrhea, and turbid peritoneal fluid after being diagnosed with peritoneal dialysis-related peritonitis. Repeated peritoneal fluid culture tests yielded negative results. After ineffective anti-infection treatment, the possibility of peritoneal dialysis-related refractory peritonitis was considered. Metagenomic next-generation sequencing （mNGS） pathogenic examination revealed the presence of Bacteroides thetaiotaomicron infection. She was recovered and discharged after combined use of metronidazole combined with imipenem and cilastatin sodium for 18 d. No recurrence of peritonitis was observed during follow-up. The diagnosis and treatment of this case prompt that attention should be paid to peritoneal dialysis-related peritonitis caused by anaerobic bacterial infection. mNGS can be applied in the routine examination of peritoneal dialysis-related peritonitis, aiming to improve the detection rate of pathogenic microorganisms, promptly select appropriate antibiotics for anti-infection therapy and enhance clinical prognosis of patients.https://www.xinyixue.cn/fileup/0253-9802/PDF/1658129473336-740502729.pdf|peritoneal dialysis-related peritonitis|bacteroides thetaiotaomicron|anaerobic bacteria|mngs |
| spellingShingle | Lu Dongli, Liu Tonghuan, Wang Lixin, Lin Junjie Successful diagnosis and treatment of refractory peritonitis caused by Bacteroides thetaiotaomicron by high-throughput sequencing: a case report Xin yixue |peritoneal dialysis-related peritonitis|bacteroides thetaiotaomicron|anaerobic bacteria|mngs |
| title | Successful diagnosis and treatment of refractory peritonitis caused by Bacteroides thetaiotaomicron by high-throughput sequencing: a case report |
| title_full | Successful diagnosis and treatment of refractory peritonitis caused by Bacteroides thetaiotaomicron by high-throughput sequencing: a case report |
| title_fullStr | Successful diagnosis and treatment of refractory peritonitis caused by Bacteroides thetaiotaomicron by high-throughput sequencing: a case report |
| title_full_unstemmed | Successful diagnosis and treatment of refractory peritonitis caused by Bacteroides thetaiotaomicron by high-throughput sequencing: a case report |
| title_short | Successful diagnosis and treatment of refractory peritonitis caused by Bacteroides thetaiotaomicron by high-throughput sequencing: a case report |
| title_sort | successful diagnosis and treatment of refractory peritonitis caused by bacteroides thetaiotaomicron by high throughput sequencing a case report |
| topic | |peritoneal dialysis-related peritonitis|bacteroides thetaiotaomicron|anaerobic bacteria|mngs |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1658129473336-740502729.pdf |
| work_keys_str_mv | AT ludongliliutonghuanwanglixinlinjunjie successfuldiagnosisandtreatmentofrefractoryperitonitiscausedbybacteroidesthetaiotaomicronbyhighthroughputsequencingacasereport |