Active information maintenance in working memory by a sensory cortex
Working memory is a critical brain function for maintaining and manipulating information over delay periods of seconds. It is debated whether delay-period neural activity in sensory regions is important for the active maintenance of information during the delay period. Here, we tackle this question...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-06-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/43191 |
| _version_ | 1828167599990505472 |
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| author | Xiaoxing Zhang Wenjun Yan Wenliang Wang Hongmei Fan Ruiqing Hou Yulei Chen Zhaoqin Chen Chaofan Ge Shumin Duan Albert Compte Chengyu T Li |
| author_facet | Xiaoxing Zhang Wenjun Yan Wenliang Wang Hongmei Fan Ruiqing Hou Yulei Chen Zhaoqin Chen Chaofan Ge Shumin Duan Albert Compte Chengyu T Li |
| author_sort | Xiaoxing Zhang |
| collection | DOAJ |
| description | Working memory is a critical brain function for maintaining and manipulating information over delay periods of seconds. It is debated whether delay-period neural activity in sensory regions is important for the active maintenance of information during the delay period. Here, we tackle this question by examining the anterior piriform cortex (APC), an olfactory sensory cortex, in head-fixed mice performing several olfactory working memory tasks. Active information maintenance is necessary in these tasks, especially in a dual-task paradigm in which mice are required to perform another distracting task while actively maintaining information during the delay period. Optogenetic suppression of neuronal activity in APC during the delay period impaired performance in all the tasks. Furthermore, electrophysiological recordings revealed that APC neuronal populations encoded odor information in the delay period even with an intervening distracting task. Thus, delay activity in APC is important for active information maintenance in olfactory working memory. |
| first_indexed | 2024-04-12T02:20:02Z |
| format | Article |
| id | doaj.art-7be7285f6b63458b97d4bc2d0367095f |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:20:02Z |
| publishDate | 2019-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-7be7285f6b63458b97d4bc2d0367095f2022-12-22T03:52:09ZengeLife Sciences Publications LtdeLife2050-084X2019-06-01810.7554/eLife.43191Active information maintenance in working memory by a sensory cortexXiaoxing Zhang0https://orcid.org/0000-0001-5229-6091Wenjun Yan1Wenliang Wang2Hongmei Fan3Ruiqing Hou4Yulei Chen5Zhaoqin Chen6Chaofan Ge7Shumin Duan8Albert Compte9Chengyu T Li10https://orcid.org/0000-0001-6829-0209State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China; School of Future Technology, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, ChinaState Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, China; School of Future Technology, University of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Medical Neurobiology of Ministry of Health of China, Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Neurobiology of Zhejiang Province, Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, ChinaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainState Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Shanghai Center for Brain Science and Brain-Inspired Technology, Chinese Academy of Sciences, Shanghai, ChinaWorking memory is a critical brain function for maintaining and manipulating information over delay periods of seconds. It is debated whether delay-period neural activity in sensory regions is important for the active maintenance of information during the delay period. Here, we tackle this question by examining the anterior piriform cortex (APC), an olfactory sensory cortex, in head-fixed mice performing several olfactory working memory tasks. Active information maintenance is necessary in these tasks, especially in a dual-task paradigm in which mice are required to perform another distracting task while actively maintaining information during the delay period. Optogenetic suppression of neuronal activity in APC during the delay period impaired performance in all the tasks. Furthermore, electrophysiological recordings revealed that APC neuronal populations encoded odor information in the delay period even with an intervening distracting task. Thus, delay activity in APC is important for active information maintenance in olfactory working memory.https://elifesciences.org/articles/43191working memorydual-taskdelay-period activityanterior piriform cortexoptogeneticspopulation neural activity |
| spellingShingle | Xiaoxing Zhang Wenjun Yan Wenliang Wang Hongmei Fan Ruiqing Hou Yulei Chen Zhaoqin Chen Chaofan Ge Shumin Duan Albert Compte Chengyu T Li Active information maintenance in working memory by a sensory cortex eLife working memory dual-task delay-period activity anterior piriform cortex optogenetics population neural activity |
| title | Active information maintenance in working memory by a sensory cortex |
| title_full | Active information maintenance in working memory by a sensory cortex |
| title_fullStr | Active information maintenance in working memory by a sensory cortex |
| title_full_unstemmed | Active information maintenance in working memory by a sensory cortex |
| title_short | Active information maintenance in working memory by a sensory cortex |
| title_sort | active information maintenance in working memory by a sensory cortex |
| topic | working memory dual-task delay-period activity anterior piriform cortex optogenetics population neural activity |
| url | https://elifesciences.org/articles/43191 |
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