Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites
Microbial secondary metabolites are an important source of antibiotics currently available for combating drug-resistant pathogens. These important secondary metabolites are produced by various microorganisms, including Actinobacteria. Actinobacteria have a colossal genome with a wide array of genes...
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MDPI AG
2022-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/7/1349 |
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| author | Galana Siro Atanas Pipite Ketan Christi Sathiyaraj Srinivasan Ramesh Subramani |
| author_facet | Galana Siro Atanas Pipite Ketan Christi Sathiyaraj Srinivasan Ramesh Subramani |
| author_sort | Galana Siro |
| collection | DOAJ |
| description | Microbial secondary metabolites are an important source of antibiotics currently available for combating drug-resistant pathogens. These important secondary metabolites are produced by various microorganisms, including Actinobacteria. Actinobacteria have a colossal genome with a wide array of genes that code for several bioactive metabolites and enzymes. Numerous studies have reported the isolation and screening of millions of strains of actinomycetes from various habitats for specialized metabolites worldwide. Looking at the extent of the importance of actinomycetes in various fields, corals are highlighted as a potential hotspot for untapped secondary metabolites and new bioactive metabolites. Unfortunately, knowledge about the diversity, distribution and biochemistry of marine actinomycetes compared to hard corals is limited. In this review, we aim to summarize the recent knowledge on the isolation, diversity, distribution and discovery of natural compounds from marine actinomycetes associated with hard corals. A total of 11 new species of actinomycetes, representing nine different families of actinomycetes, were recovered from hard corals during the period from 2007 to 2022. In addition, this study examined a total of 13 new compounds produced by five genera of actinomycetes reported from 2017 to 2022 with antibacterial, antifungal and cytotoxic activities. Coral-derived actinomycetes have different mechanisms of action against their competitors. |
| first_indexed | 2024-03-09T06:10:30Z |
| format | Article |
| id | doaj.art-7bea04dbdb2143839c36b2735126746b |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T06:10:30Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-7bea04dbdb2143839c36b2735126746b2023-12-03T11:58:58ZengMDPI AGMicroorganisms2076-26072022-07-01107134910.3390/microorganisms10071349Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized MetabolitesGalana Siro0Atanas Pipite1Ketan Christi2Sathiyaraj Srinivasan3Ramesh Subramani4School of Agriculture, Geography, Environment, Ocean and Natural Sciences (SAGEONS), The University of the South Pacific, Laucala Campus, Suva, FijiSchool of Agriculture, Geography, Environment, Ocean and Natural Sciences (SAGEONS), The University of the South Pacific, Laucala Campus, Suva, FijiSchool of Agriculture, Geography, Environment, Ocean and Natural Sciences (SAGEONS), The University of the South Pacific, Laucala Campus, Suva, FijiDepartment of Bio & Environmental Technology, Division of Environmental & Life Science, College of Natural Science, Seoul Women’s University, 623 Hwarangno, Nowon-gu, Seoul 01797, KoreaSchool of Agriculture, Geography, Environment, Ocean and Natural Sciences (SAGEONS), The University of the South Pacific, Laucala Campus, Suva, FijiMicrobial secondary metabolites are an important source of antibiotics currently available for combating drug-resistant pathogens. These important secondary metabolites are produced by various microorganisms, including Actinobacteria. Actinobacteria have a colossal genome with a wide array of genes that code for several bioactive metabolites and enzymes. Numerous studies have reported the isolation and screening of millions of strains of actinomycetes from various habitats for specialized metabolites worldwide. Looking at the extent of the importance of actinomycetes in various fields, corals are highlighted as a potential hotspot for untapped secondary metabolites and new bioactive metabolites. Unfortunately, knowledge about the diversity, distribution and biochemistry of marine actinomycetes compared to hard corals is limited. In this review, we aim to summarize the recent knowledge on the isolation, diversity, distribution and discovery of natural compounds from marine actinomycetes associated with hard corals. A total of 11 new species of actinomycetes, representing nine different families of actinomycetes, were recovered from hard corals during the period from 2007 to 2022. In addition, this study examined a total of 13 new compounds produced by five genera of actinomycetes reported from 2017 to 2022 with antibacterial, antifungal and cytotoxic activities. Coral-derived actinomycetes have different mechanisms of action against their competitors.https://www.mdpi.com/2076-2607/10/7/1349marine actinomycetesactinobacteriamicrobial secondary metabolitescleractinian coralantimicrobial resistance |
| spellingShingle | Galana Siro Atanas Pipite Ketan Christi Sathiyaraj Srinivasan Ramesh Subramani Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites Microorganisms marine actinomycetes actinobacteria microbial secondary metabolite scleractinian coral antimicrobial resistance |
| title | Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites |
| title_full | Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites |
| title_fullStr | Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites |
| title_full_unstemmed | Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites |
| title_short | Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites |
| title_sort | marine actinomycetes associated with stony corals a potential hotspot for specialized metabolites |
| topic | marine actinomycetes actinobacteria microbial secondary metabolite scleractinian coral antimicrobial resistance |
| url | https://www.mdpi.com/2076-2607/10/7/1349 |
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