Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility
BackgroundApproximately 35% of individuals over age 70 report difficulty with mobility. Muscle weakness has been demonstrated to be one contributor to mobility limitations in older adults. The purpose of this study was to examine the moderating effect of brain-predicted age difference (an index of b...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.808022/full |
| _version_ | 1798024748436815872 |
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| author | Brooke A. Vaughan Brooke A. Vaughan Janet E. Simon Janet E. Simon Dustin R. Grooms Dustin R. Grooms Dustin R. Grooms Leatha A. Clark Leatha A. Clark Leatha A. Clark Nathan P. Wages Nathan P. Wages Brian C. Clark Brian C. Clark |
| author_facet | Brooke A. Vaughan Brooke A. Vaughan Janet E. Simon Janet E. Simon Dustin R. Grooms Dustin R. Grooms Dustin R. Grooms Leatha A. Clark Leatha A. Clark Leatha A. Clark Nathan P. Wages Nathan P. Wages Brian C. Clark Brian C. Clark |
| author_sort | Brooke A. Vaughan |
| collection | DOAJ |
| description | BackgroundApproximately 35% of individuals over age 70 report difficulty with mobility. Muscle weakness has been demonstrated to be one contributor to mobility limitations in older adults. The purpose of this study was to examine the moderating effect of brain-predicted age difference (an index of biological brain age/health derived from structural neuroimaging) on the relationship between leg strength and mobility.MethodsIn community dwelling older adults (N = 57, 74.7 ± 6.93 years; 68% women), we assessed the relationship between isokinetic leg extensor strength and a composite measure of mobility [mobility battery assessment (MBA)] using partial Pearson correlations and multifactorial regression modeling. Brain predicted age (BPA) was calculated from T1 MR-images using a validated machine learning Gaussian Process regression model to explore the moderating effect of BPA difference (BPAD; BPA minus chronological age).ResultsLeg strength was significantly correlated with BPAD (r = −0.317, p < 0.05) and MBA score (r = 0.541, p < 0.001). Chronological age, sex, leg strength, and BPAD explained 63% of the variance in MBA performance (p < 0.001). BPAD was a significant moderator of the relationship between strength and MBA, accounting for 7.0% of MBA score variance [△R2 = 0.044, F(1,51) = 6.83, p = 0.01]. Conditional moderation effects of BPAD indicate strength was a stronger predictor of mobility in those with a great BPAD.ConclusionThe relationship between strength and mobility appears to be influenced by brain aging, with strength serving as a possible compensation for decline in neural integrity. |
| first_indexed | 2024-04-11T18:07:37Z |
| format | Article |
| id | doaj.art-7bea83c5f98d48dfb38b1f8708765de5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T18:07:37Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-7bea83c5f98d48dfb38b1f8708765de52022-12-22T04:10:16ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-01-011410.3389/fnagi.2022.808022808022Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and MobilityBrooke A. Vaughan0Brooke A. Vaughan1Janet E. Simon2Janet E. Simon3Dustin R. Grooms4Dustin R. Grooms5Dustin R. Grooms6Leatha A. Clark7Leatha A. Clark8Leatha A. Clark9Nathan P. Wages10Nathan P. Wages11Brian C. Clark12Brian C. Clark13Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United StatesSchool of Rehabilitation and Communication Sciences, Ohio University, Athens, OH, United StatesOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United StatesSchool of Applied Health Sciences and Wellness, Ohio University, Athens, OH, United StatesOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United StatesSchool of Rehabilitation and Communication Sciences, Ohio University, Athens, OH, United StatesSchool of Applied Health Sciences and Wellness, Ohio University, Athens, OH, United StatesOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United StatesDepartment of Biomedical Sciences, Ohio University, Athens, OH, United StatesDepartment of Family Medicine, Ohio University, Athens, OH, United StatesOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United StatesDepartment of Biomedical Sciences, Ohio University, Athens, OH, United StatesOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United StatesDepartment of Biomedical Sciences, Ohio University, Athens, OH, United StatesBackgroundApproximately 35% of individuals over age 70 report difficulty with mobility. Muscle weakness has been demonstrated to be one contributor to mobility limitations in older adults. The purpose of this study was to examine the moderating effect of brain-predicted age difference (an index of biological brain age/health derived from structural neuroimaging) on the relationship between leg strength and mobility.MethodsIn community dwelling older adults (N = 57, 74.7 ± 6.93 years; 68% women), we assessed the relationship between isokinetic leg extensor strength and a composite measure of mobility [mobility battery assessment (MBA)] using partial Pearson correlations and multifactorial regression modeling. Brain predicted age (BPA) was calculated from T1 MR-images using a validated machine learning Gaussian Process regression model to explore the moderating effect of BPA difference (BPAD; BPA minus chronological age).ResultsLeg strength was significantly correlated with BPAD (r = −0.317, p < 0.05) and MBA score (r = 0.541, p < 0.001). Chronological age, sex, leg strength, and BPAD explained 63% of the variance in MBA performance (p < 0.001). BPAD was a significant moderator of the relationship between strength and MBA, accounting for 7.0% of MBA score variance [△R2 = 0.044, F(1,51) = 6.83, p = 0.01]. Conditional moderation effects of BPAD indicate strength was a stronger predictor of mobility in those with a great BPAD.ConclusionThe relationship between strength and mobility appears to be influenced by brain aging, with strength serving as a possible compensation for decline in neural integrity.https://www.frontiersin.org/articles/10.3389/fnagi.2022.808022/fullweaknessphysical functionsarcopeniabrain agingdynapenia |
| spellingShingle | Brooke A. Vaughan Brooke A. Vaughan Janet E. Simon Janet E. Simon Dustin R. Grooms Dustin R. Grooms Dustin R. Grooms Leatha A. Clark Leatha A. Clark Leatha A. Clark Nathan P. Wages Nathan P. Wages Brian C. Clark Brian C. Clark Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility Frontiers in Aging Neuroscience weakness physical function sarcopenia brain aging dynapenia |
| title | Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility |
| title_full | Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility |
| title_fullStr | Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility |
| title_full_unstemmed | Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility |
| title_short | Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility |
| title_sort | brain predicted age difference moderates the association between muscle strength and mobility |
| topic | weakness physical function sarcopenia brain aging dynapenia |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.808022/full |
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