Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2

Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2

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Loss of function of the neurofibromatosis type 2 (NF2) tumor suppressor gene leads to the formation of schwannomas, meningiomas, and ependymomas, comprising ∼50% of all sporadic cases of primary nervous system tumors. NF2 syndrome is an autosomal dominant condition, with bi-allelic inactivation of g...

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Bibliographic Details
Main Authors: Shilpa Prabhakar, Roberta L. Beauchamp, Pike See Cheah, Akiko Yoshinaga, Edwina Abou Haidar, Sevda Lule, Gayathri Mani, Katia Maalouf, Anat Stemmer-Rachamimov, David H. Jung, D. Bradley Welling, Marco Giovannini, Scott R. Plotkin, Casey A. Maguire, Vijaya Ramesh, Xandra O. Breakefield
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
neurofibromatosis type 2
gene therapy
adeno-associated viral vector
schwannoma
Schwann cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000912

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