Topical use of dexpanthenol: a 70th anniversary article
Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen™ Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-11-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2017.1325310 |
| _version_ | 1797683746066923520 |
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| author | Ehrhardt Proksch Raymond de Bony Sonja Trapp Stéphanie Boudon |
| author_facet | Ehrhardt Proksch Raymond de Bony Sonja Trapp Stéphanie Boudon |
| author_sort | Ehrhardt Proksch |
| collection | DOAJ |
| description | Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen™ Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol’s moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Two main directions in the use of topical dexpanthenol-containing formulations have therefore been pursued: as skin moisturizer/skin barrier restorer and as facilitator of wound healing. This 70th anniversary paper reviews studies with topical dexpanthenol in skin conditions where it is most frequently used. Although discovered decades ago, the exact mechanisms of action of dexpanthenol have not been fully elucidated yet. With the adoption of new technologies, new light has been shed on dexpanthenol’s mode of action at the molecular level. It appears that dexpanthenol increases the mobility of stratum corneum molecular components which are important for barrier function and modulates the expression of genes important for wound healing. This review will update readers on recent advances in this field. |
| first_indexed | 2024-03-12T00:19:15Z |
| format | Article |
| id | doaj.art-7beb3ac85a69449897431d2d9ed712a6 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:19:15Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-7beb3ac85a69449897431d2d9ed712a62023-09-15T14:08:30ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532017-11-0128876677310.1080/09546634.2017.13253101325310Topical use of dexpanthenol: a 70th anniversary articleEhrhardt Proksch0Raymond de Bony1Sonja Trapp2Stéphanie Boudon3University of KielBayer Consumer Care AGBayer Consumer Care AGBayer Consumer Care AGApproximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen™ Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol’s moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Two main directions in the use of topical dexpanthenol-containing formulations have therefore been pursued: as skin moisturizer/skin barrier restorer and as facilitator of wound healing. This 70th anniversary paper reviews studies with topical dexpanthenol in skin conditions where it is most frequently used. Although discovered decades ago, the exact mechanisms of action of dexpanthenol have not been fully elucidated yet. With the adoption of new technologies, new light has been shed on dexpanthenol’s mode of action at the molecular level. It appears that dexpanthenol increases the mobility of stratum corneum molecular components which are important for barrier function and modulates the expression of genes important for wound healing. This review will update readers on recent advances in this field.http://dx.doi.org/10.1080/09546634.2017.1325310bepanthendexpanthenolskintopicalanniversary |
| spellingShingle | Ehrhardt Proksch Raymond de Bony Sonja Trapp Stéphanie Boudon Topical use of dexpanthenol: a 70th anniversary article Journal of Dermatological Treatment bepanthen dexpanthenol skin topical anniversary |
| title | Topical use of dexpanthenol: a 70th anniversary article |
| title_full | Topical use of dexpanthenol: a 70th anniversary article |
| title_fullStr | Topical use of dexpanthenol: a 70th anniversary article |
| title_full_unstemmed | Topical use of dexpanthenol: a 70th anniversary article |
| title_short | Topical use of dexpanthenol: a 70th anniversary article |
| title_sort | topical use of dexpanthenol a 70th anniversary article |
| topic | bepanthen dexpanthenol skin topical anniversary |
| url | http://dx.doi.org/10.1080/09546634.2017.1325310 |
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