MICA and KIR: Immunogenetic Factors Influencing Left Ventricular Systolic Dysfunction and Digestive Clinical Form of Chronic Chagas Disease
Tissue damage observed in the clinical forms of chronic symptomatic Chagas disease seems to have a close relationship with the intensity of the inflammatory process. The objective of this study was to investigate whether the MICA (MHC class I-related chain A) and KIR (killer cell immunoglobulin-like...
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.714766/full |
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| author | Christiane Maria Ayo Reinaldo Bulgarelli Bestetti Eumildo de Campos Junior Luiz Sérgio Ronchi Aldenis Albaneze Borim Cinara Cássia Brandão Luiz Carlos de Matttos |
| author_facet | Christiane Maria Ayo Reinaldo Bulgarelli Bestetti Eumildo de Campos Junior Luiz Sérgio Ronchi Aldenis Albaneze Borim Cinara Cássia Brandão Luiz Carlos de Matttos |
| author_sort | Christiane Maria Ayo |
| collection | DOAJ |
| description | Tissue damage observed in the clinical forms of chronic symptomatic Chagas disease seems to have a close relationship with the intensity of the inflammatory process. The objective of this study was to investigate whether the MICA (MHC class I-related chain A) and KIR (killer cell immunoglobulin-like receptors) polymorphisms are associated with the cardiac and digestive clinical forms of chronic Chagas disease. Possible influence of these genes polymorphisms on the left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease was also evaluated. This study enrolled 185 patients with positive serology for Trypanosoma cruzi classified according to the clinical form of the disease: cardiac (n=107) and digestive (n=78). Subsequently, patients with the cardiac form of the disease were sub-classified as with LVSD (n=52) and without LVSD (n=55). A control group was formed of 110 healthy individuals. Genotyping was performed by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP). Statistical analyzes were carried out using the Chi-square test and odds ratio with 95% confidence interval was also calculated to evaluate the risk association. MICA-129 allele with high affinity for the NKG2D receptor was associated to the LVSD in patients with CCHD. The haplotype MICA*008~HLA-C*06 and the KIR2DS2-/KIR2DL2-/KIR2DL3+/C1+ combination were associated to the digestive clinical form of the disease. Our data showed that the MICA and KIR polymorphisms may exert a role in the LVSD of cardiac patients, and in digestive form of Chagas disease. |
| first_indexed | 2024-12-16T18:51:53Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T18:51:53Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7bebe287266f4ae2aec441f2bc50e0192022-12-21T22:20:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-08-011210.3389/fimmu.2021.714766714766MICA and KIR: Immunogenetic Factors Influencing Left Ventricular Systolic Dysfunction and Digestive Clinical Form of Chronic Chagas DiseaseChristiane Maria Ayo0Reinaldo Bulgarelli Bestetti1Eumildo de Campos Junior2Luiz Sérgio Ronchi3Aldenis Albaneze Borim4Cinara Cássia Brandão5Luiz Carlos de Matttos6Immunogenetics Laboratory, Molecular Biology Department, Medicine School in São José do Rio Preto, São José do Rio Preto, BrazilDepartment of Cardiology and Cardiovascular Surgery, Medicine School in São José do Rio Preto, São José do Rio Preto, BrazilSurgery Department, Medicine School in São José do Rio Preto, São José do Rio Preto, BrazilSurgery Department, Medicine School in São José do Rio Preto, São José do Rio Preto, BrazilSurgery Department, Medicine School in São José do Rio Preto, São José do Rio Preto, BrazilImmunogenetics Laboratory, Molecular Biology Department, Medicine School in São José do Rio Preto, São José do Rio Preto, BrazilImmunogenetics Laboratory, Molecular Biology Department, Medicine School in São José do Rio Preto, São José do Rio Preto, BrazilTissue damage observed in the clinical forms of chronic symptomatic Chagas disease seems to have a close relationship with the intensity of the inflammatory process. The objective of this study was to investigate whether the MICA (MHC class I-related chain A) and KIR (killer cell immunoglobulin-like receptors) polymorphisms are associated with the cardiac and digestive clinical forms of chronic Chagas disease. Possible influence of these genes polymorphisms on the left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease was also evaluated. This study enrolled 185 patients with positive serology for Trypanosoma cruzi classified according to the clinical form of the disease: cardiac (n=107) and digestive (n=78). Subsequently, patients with the cardiac form of the disease were sub-classified as with LVSD (n=52) and without LVSD (n=55). A control group was formed of 110 healthy individuals. Genotyping was performed by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP). Statistical analyzes were carried out using the Chi-square test and odds ratio with 95% confidence interval was also calculated to evaluate the risk association. MICA-129 allele with high affinity for the NKG2D receptor was associated to the LVSD in patients with CCHD. The haplotype MICA*008~HLA-C*06 and the KIR2DS2-/KIR2DL2-/KIR2DL3+/C1+ combination were associated to the digestive clinical form of the disease. Our data showed that the MICA and KIR polymorphisms may exert a role in the LVSD of cardiac patients, and in digestive form of Chagas disease.https://www.frontiersin.org/articles/10.3389/fimmu.2021.714766/fullMHC class IKIR receptorsChagas diseasechronic chagasic heart diseasechagasic megacolonchagasic megaesophagus |
| spellingShingle | Christiane Maria Ayo Reinaldo Bulgarelli Bestetti Eumildo de Campos Junior Luiz Sérgio Ronchi Aldenis Albaneze Borim Cinara Cássia Brandão Luiz Carlos de Matttos MICA and KIR: Immunogenetic Factors Influencing Left Ventricular Systolic Dysfunction and Digestive Clinical Form of Chronic Chagas Disease Frontiers in Immunology MHC class I KIR receptors Chagas disease chronic chagasic heart disease chagasic megacolon chagasic megaesophagus |
| title | MICA and KIR: Immunogenetic Factors Influencing Left Ventricular Systolic Dysfunction and Digestive Clinical Form of Chronic Chagas Disease |
| title_full | MICA and KIR: Immunogenetic Factors Influencing Left Ventricular Systolic Dysfunction and Digestive Clinical Form of Chronic Chagas Disease |
| title_fullStr | MICA and KIR: Immunogenetic Factors Influencing Left Ventricular Systolic Dysfunction and Digestive Clinical Form of Chronic Chagas Disease |
| title_full_unstemmed | MICA and KIR: Immunogenetic Factors Influencing Left Ventricular Systolic Dysfunction and Digestive Clinical Form of Chronic Chagas Disease |
| title_short | MICA and KIR: Immunogenetic Factors Influencing Left Ventricular Systolic Dysfunction and Digestive Clinical Form of Chronic Chagas Disease |
| title_sort | mica and kir immunogenetic factors influencing left ventricular systolic dysfunction and digestive clinical form of chronic chagas disease |
| topic | MHC class I KIR receptors Chagas disease chronic chagasic heart disease chagasic megacolon chagasic megaesophagus |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.714766/full |
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