Single Loading Low Dose MgSO₄ Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian Women
Introduction: Magnesium sulphate is the anticonvulsant of choice in prevention and control of eclamptic convulsions. Pritchard’s regimen is the most popular time-tested regimen used. However, owing to concerns of toxicity, several low dose regimens have been introduced considering the lower body...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10453/26635_CE[Ra]_F(Sh)_PF1[NE_VT_AP].pdf |
| _version_ | 1811317094779715584 |
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| author | Tripti Nagaria Subarna Mitra Sashi Prabha Banjare |
| author_facet | Tripti Nagaria Subarna Mitra Sashi Prabha Banjare |
| author_sort | Tripti Nagaria |
| collection | DOAJ |
| description | Introduction: Magnesium sulphate is the anticonvulsant of
choice in prevention and control of eclamptic convulsions.
Pritchard’s regimen is the most popular time-tested regimen
used. However, owing to concerns of toxicity, several low dose
regimens have been introduced considering the lower body
mass index of Asian women.
Aim: To compare the efficacy and safety of a single loading low
dose MgSo4
regimen with the Pritchard’s regimen.
Materials and Methods: Seventy cases of eclampsia and
imminent eclampsia were allocated to the control and study
groups each. The former received the Pritchard’s regimen while
the latter was treated with single loading low dose of magnesium
sulphate. Recurrent convulsion rates, maternal and perinatal
outcomes of both regimens were evaluated and compared
using unpaired t-test and Chi-square test for continuous and
categorical variables, respectively.
Results: The mean serum magnesium levels were significantly
lower in the study group at 30 minutes and 4 hours of initiation
of therapy. The single loading low dose regimen was equally
efficacious in prevention (96.6% vs 100%, p = 0.934) and control
(97.6% vs 97.8%, p = 0.358) of eclamptic fits as compared to
the Pritchard’s regimen. The feto-maternal outcomes were also
comparable.
Conclusion: The single loading low dose MgSo4 regimen is
an effective and safe alternative to the Pritchard’s regimen,
especially tailored to the small built Indian women. |
| first_indexed | 2024-04-13T12:00:30Z |
| format | Article |
| id | doaj.art-7bed1d911376460fa5f1045fab92587a |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-13T12:00:30Z |
| publishDate | 2017-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-7bed1d911376460fa5f1045fab92587a2022-12-22T02:47:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-08-01118QC08QC1210.7860/JCDR/2017/26635.10453Single Loading Low Dose MgSO₄ Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian WomenTripti Nagaria0Subarna Mitra1Sashi Prabha Banjare2Professor, Department of Obstetrics and Gynaecology, Pt. Jawaharlal Nehru Medical College and Hospital, Raipur, Chhattisgarh, India.Assistant Professor, Department of Obstetrics and Gynaecology, Pt. Jawaharlal Nehru Medical College and Hospital, Raipur, Chhattisgarh, India.Junior Resident, Department of Obstetrics and Gynaecology, Pt. Jawaharlal Nehru Medical College and Hospital, Raipur, Chhattisgarh, India.Introduction: Magnesium sulphate is the anticonvulsant of choice in prevention and control of eclamptic convulsions. Pritchard’s regimen is the most popular time-tested regimen used. However, owing to concerns of toxicity, several low dose regimens have been introduced considering the lower body mass index of Asian women. Aim: To compare the efficacy and safety of a single loading low dose MgSo4 regimen with the Pritchard’s regimen. Materials and Methods: Seventy cases of eclampsia and imminent eclampsia were allocated to the control and study groups each. The former received the Pritchard’s regimen while the latter was treated with single loading low dose of magnesium sulphate. Recurrent convulsion rates, maternal and perinatal outcomes of both regimens were evaluated and compared using unpaired t-test and Chi-square test for continuous and categorical variables, respectively. Results: The mean serum magnesium levels were significantly lower in the study group at 30 minutes and 4 hours of initiation of therapy. The single loading low dose regimen was equally efficacious in prevention (96.6% vs 100%, p = 0.934) and control (97.6% vs 97.8%, p = 0.358) of eclamptic fits as compared to the Pritchard’s regimen. The feto-maternal outcomes were also comparable. Conclusion: The single loading low dose MgSo4 regimen is an effective and safe alternative to the Pritchard’s regimen, especially tailored to the small built Indian women.https://jcdr.net/articles/PDF/10453/26635_CE[Ra]_F(Sh)_PF1[NE_VT_AP].pdfeclampsialow dose magnesium sulphaterecurrent convulsion |
| spellingShingle | Tripti Nagaria Subarna Mitra Sashi Prabha Banjare Single Loading Low Dose MgSO₄ Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian Women Journal of Clinical and Diagnostic Research eclampsia low dose magnesium sulphate recurrent convulsion |
| title | Single Loading Low Dose MgSO₄ Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian Women |
| title_full | Single Loading Low Dose MgSO₄ Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian Women |
| title_fullStr | Single Loading Low Dose MgSO₄ Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian Women |
| title_full_unstemmed | Single Loading Low Dose MgSO₄ Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian Women |
| title_short | Single Loading Low Dose MgSO₄ Regimen: A Simple, Safe and Effective Alternative to Pritchard’s Regimen for Indian Women |
| title_sort | single loading low dose mgso₄ regimen a simple safe and effective alternative to pritchard s regimen for indian women |
| topic | eclampsia low dose magnesium sulphate recurrent convulsion |
| url | https://jcdr.net/articles/PDF/10453/26635_CE[Ra]_F(Sh)_PF1[NE_VT_AP].pdf |
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