Pulp-dentin regeneration: current approaches and challenges
Regenerative endodontic procedures for immature permanent teeth with apical periodontitis confer biological advantages such as tooth homeostasis, enhanced immune defense system, and a functional pulp-dentin complex, in addition to clinical advantages such as the facilitation of root development. Cur...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-01-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/2041731418819263 |
| _version_ | 1819227152974872576 |
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| author | Chanyong Jung Sangwan Kim Taeuk Sun Yong-Bum Cho Minju Song |
| author_facet | Chanyong Jung Sangwan Kim Taeuk Sun Yong-Bum Cho Minju Song |
| author_sort | Chanyong Jung |
| collection | DOAJ |
| description | Regenerative endodontic procedures for immature permanent teeth with apical periodontitis confer biological advantages such as tooth homeostasis, enhanced immune defense system, and a functional pulp-dentin complex, in addition to clinical advantages such as the facilitation of root development. Currently, this procedure is recognized as a paradigm shift from restoration using materials to regenerate pulp-dentin tissues. Many studies have been conducted with regard to stem/progenitor cells, scaffolds, and biomolecules, associated with pulp tissue engineering. However, preclinical and clinical studies have evidently revealed several drawbacks in the current clinical approach to revascularization that may lead to unfavorable outcomes. Therefore, our review examines the challenges encountered under clinical conditions and summarizes current research findings in an attempt to provide direction for transition from basic research to clinical practice. |
| first_indexed | 2024-12-23T10:36:51Z |
| format | Article |
| id | doaj.art-7bed81191317424b9b450e18cd8b77c4 |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-23T10:36:51Z |
| publishDate | 2019-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-7bed81191317424b9b450e18cd8b77c42022-12-21T17:50:16ZengSAGE PublishingJournal of Tissue Engineering2041-73142019-01-011010.1177/2041731418819263Pulp-dentin regeneration: current approaches and challengesChanyong Jung0Sangwan Kim1Taeuk Sun2Yong-Bum Cho3Minju Song4Department of Conservative Dentistry, College of Dentistry, Dankook University, Cheonan, KoreaDepartment of Conservative Dentistry, College of Dentistry, Dankook University, Cheonan, KoreaDepartment of Conservative Dentistry, College of Dentistry, Dankook University, Cheonan, KoreaDepartment of Conservative Dentistry, College of Dentistry, Dankook University, Cheonan, KoreaDepartment of Conservative Dentistry, College of Dentistry, Dankook University, Cheonan, KoreaRegenerative endodontic procedures for immature permanent teeth with apical periodontitis confer biological advantages such as tooth homeostasis, enhanced immune defense system, and a functional pulp-dentin complex, in addition to clinical advantages such as the facilitation of root development. Currently, this procedure is recognized as a paradigm shift from restoration using materials to regenerate pulp-dentin tissues. Many studies have been conducted with regard to stem/progenitor cells, scaffolds, and biomolecules, associated with pulp tissue engineering. However, preclinical and clinical studies have evidently revealed several drawbacks in the current clinical approach to revascularization that may lead to unfavorable outcomes. Therefore, our review examines the challenges encountered under clinical conditions and summarizes current research findings in an attempt to provide direction for transition from basic research to clinical practice.https://doi.org/10.1177/2041731418819263 |
| spellingShingle | Chanyong Jung Sangwan Kim Taeuk Sun Yong-Bum Cho Minju Song Pulp-dentin regeneration: current approaches and challenges Journal of Tissue Engineering |
| title | Pulp-dentin regeneration: current approaches and challenges |
| title_full | Pulp-dentin regeneration: current approaches and challenges |
| title_fullStr | Pulp-dentin regeneration: current approaches and challenges |
| title_full_unstemmed | Pulp-dentin regeneration: current approaches and challenges |
| title_short | Pulp-dentin regeneration: current approaches and challenges |
| title_sort | pulp dentin regeneration current approaches and challenges |
| url | https://doi.org/10.1177/2041731418819263 |
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