Refractive error as a risk factor in patients with Macular Telangiectasia type 2A: A case-control study
Aim: The purpose of the study was to determine the role of refractive error as a potential risk factor for macular telangiectasia (MacTel) 2A. Subjects and Methods: The study was designed as a hospital-based retrospective case–control study. One hundred and three age- and sex-matched participants se...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Kerala Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.kjophthal.com/article.asp?issn=0976-6677;year=2016;volume=28;issue=3;spage=189;epage=192;aulast=Elias |
| _version_ | 1818216913193402368 |
|---|---|
| author | Anna Elias Thushar Popat Waghule Rameez N Hussain Mahesh Gopalakrishnan Giridhar Anantharaman |
| author_facet | Anna Elias Thushar Popat Waghule Rameez N Hussain Mahesh Gopalakrishnan Giridhar Anantharaman |
| author_sort | Anna Elias |
| collection | DOAJ |
| description | Aim: The purpose of the study was to determine the role of refractive error as a potential risk factor for macular telangiectasia (MacTel) 2A.
Subjects and Methods: The study was designed as a hospital-based retrospective case–control study. One hundred and three age- and sex-matched participants served as controls. The study was conducted over a 3-year period (April 2011–March 2014). The diagnosis of MacTel 2A was based on the classification by Gass JD and Blodi BA with the addition of optical coherence tomography and fundus autofluorescence features. Data from medical records were entered in a standardized pro forma and analyzed. Spherical equivalent (SEq) was calculated using the spherical dioptric power plus half the cylindrical dioptric power. Statistical analysis was performed using SPSS version 20 and statistical package R 1386 3.1.0.
Results: The mean refractive error (SEq) of the cases was +0.90D and +1.08D among the controls. The refractive errors ranged from −4.00D to +6.75D among the cases. Binary logistic regression analysis was performed to determine the role of refractive error as a risk factor for MacTel 2A. Emmetropia was taken as the reference category. Hypermetropia had an odds ratio (OR) of 2.50 (P = 0.002). Myopia had an OR of 1.50 (P = 0.29). It was inferred that patients with hypermetropia had a 2.50 times higher risk of developing MacTel 2A, compared to emmetropes.
Conclusion: Our study of 103 cases and an equal number of age- and sex-matched controls revealed that hypermetropia was a significant risk factor for the development of MacTel 2A. |
| first_indexed | 2024-12-12T06:59:31Z |
| format | Article |
| id | doaj.art-7bef578373ca490b9eea7404b6715720 |
| institution | Directory Open Access Journal |
| issn | 0976-6677 |
| language | English |
| last_indexed | 2024-12-12T06:59:31Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Kerala Journal of Ophthalmology |
| spelling | doaj.art-7bef578373ca490b9eea7404b67157202022-12-22T00:33:53ZengWolters Kluwer Medknow PublicationsKerala Journal of Ophthalmology0976-66772016-01-0128318919210.4103/kjo.kjo_13_17Refractive error as a risk factor in patients with Macular Telangiectasia type 2A: A case-control studyAnna EliasThushar Popat WaghuleRameez N HussainMahesh GopalakrishnanGiridhar AnantharamanAim: The purpose of the study was to determine the role of refractive error as a potential risk factor for macular telangiectasia (MacTel) 2A. Subjects and Methods: The study was designed as a hospital-based retrospective case–control study. One hundred and three age- and sex-matched participants served as controls. The study was conducted over a 3-year period (April 2011–March 2014). The diagnosis of MacTel 2A was based on the classification by Gass JD and Blodi BA with the addition of optical coherence tomography and fundus autofluorescence features. Data from medical records were entered in a standardized pro forma and analyzed. Spherical equivalent (SEq) was calculated using the spherical dioptric power plus half the cylindrical dioptric power. Statistical analysis was performed using SPSS version 20 and statistical package R 1386 3.1.0. Results: The mean refractive error (SEq) of the cases was +0.90D and +1.08D among the controls. The refractive errors ranged from −4.00D to +6.75D among the cases. Binary logistic regression analysis was performed to determine the role of refractive error as a risk factor for MacTel 2A. Emmetropia was taken as the reference category. Hypermetropia had an odds ratio (OR) of 2.50 (P = 0.002). Myopia had an OR of 1.50 (P = 0.29). It was inferred that patients with hypermetropia had a 2.50 times higher risk of developing MacTel 2A, compared to emmetropes. Conclusion: Our study of 103 cases and an equal number of age- and sex-matched controls revealed that hypermetropia was a significant risk factor for the development of MacTel 2A.http://www.kjophthal.com/article.asp?issn=0976-6677;year=2016;volume=28;issue=3;spage=189;epage=192;aulast=EliasFundus autofluorescenceMacTel 2Arefractive errorrisk factorsSPSS |
| spellingShingle | Anna Elias Thushar Popat Waghule Rameez N Hussain Mahesh Gopalakrishnan Giridhar Anantharaman Refractive error as a risk factor in patients with Macular Telangiectasia type 2A: A case-control study Kerala Journal of Ophthalmology Fundus autofluorescence MacTel 2A refractive error risk factors SPSS |
| title | Refractive error as a risk factor in patients with Macular Telangiectasia type 2A: A case-control study |
| title_full | Refractive error as a risk factor in patients with Macular Telangiectasia type 2A: A case-control study |
| title_fullStr | Refractive error as a risk factor in patients with Macular Telangiectasia type 2A: A case-control study |
| title_full_unstemmed | Refractive error as a risk factor in patients with Macular Telangiectasia type 2A: A case-control study |
| title_short | Refractive error as a risk factor in patients with Macular Telangiectasia type 2A: A case-control study |
| title_sort | refractive error as a risk factor in patients with macular telangiectasia type 2a a case control study |
| topic | Fundus autofluorescence MacTel 2A refractive error risk factors SPSS |
| url | http://www.kjophthal.com/article.asp?issn=0976-6677;year=2016;volume=28;issue=3;spage=189;epage=192;aulast=Elias |
| work_keys_str_mv | AT annaelias refractiveerrorasariskfactorinpatientswithmaculartelangiectasiatype2aacasecontrolstudy AT thusharpopatwaghule refractiveerrorasariskfactorinpatientswithmaculartelangiectasiatype2aacasecontrolstudy AT rameeznhussain refractiveerrorasariskfactorinpatientswithmaculartelangiectasiatype2aacasecontrolstudy AT maheshgopalakrishnan refractiveerrorasariskfactorinpatientswithmaculartelangiectasiatype2aacasecontrolstudy AT giridharanantharaman refractiveerrorasariskfactorinpatientswithmaculartelangiectasiatype2aacasecontrolstudy |