Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia
Rare variants in TTN are the most common monogenic cause of early-onset atrial fibrillation and dilated cardiomyopathy. Whereas cardiac sarcoidosis is very underdiagnosed, a common presentation can be ventricular arrhythmias. This report presents a patient with a likely pathogenic TTN variant and ca...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | JACC: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666084923001833 |
| _version_ | 1797825602077589504 |
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| author | Zain M. Virk, MD T. Lee Richardson, Jr., MD Joseph F. Nowatzke, MD Asad Ullah, MD Dawn M. Pedrotty, MD M. Benjamin Shoemaker, MD, MSCI Arvindh Kanagasundram, MD Dan M. Roden, MD William G. Stevenson, MD |
| author_facet | Zain M. Virk, MD T. Lee Richardson, Jr., MD Joseph F. Nowatzke, MD Asad Ullah, MD Dawn M. Pedrotty, MD M. Benjamin Shoemaker, MD, MSCI Arvindh Kanagasundram, MD Dan M. Roden, MD William G. Stevenson, MD |
| author_sort | Zain M. Virk, MD |
| collection | DOAJ |
| description | Rare variants in TTN are the most common monogenic cause of early-onset atrial fibrillation and dilated cardiomyopathy. Whereas cardiac sarcoidosis is very underdiagnosed, a common presentation can be ventricular arrhythmias. This report presents a patient with a likely pathogenic TTN variant and cardiac sarcoidosis. (Level of Difficulty: Intermediate.) |
| first_indexed | 2024-03-13T10:56:22Z |
| format | Article |
| id | doaj.art-7bef6f94a2db4230904b444929ace426 |
| institution | Directory Open Access Journal |
| issn | 2666-0849 |
| language | English |
| last_indexed | 2024-03-13T10:56:22Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Case Reports |
| spelling | doaj.art-7bef6f94a2db4230904b444929ace4262023-05-17T04:23:15ZengElsevierJACC: Case Reports2666-08492023-06-0116101878Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular TachycardiaZain M. Virk, MD0T. Lee Richardson, Jr., MD1Joseph F. Nowatzke, MD2Asad Ullah, MD3Dawn M. Pedrotty, MD4M. Benjamin Shoemaker, MD, MSCI5Arvindh Kanagasundram, MD6Dan M. Roden, MD7William G. Stevenson, MD8Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USAVanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA; Address for correspondence: Dr Tadarro Lee Richardson Jr, Vanderbilt University Medical Center, 2220 Pierce Avenue, 282 Preston Research Building, Nashville, Tennessee 37202, USA.Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USAVanderbilt University Medical Center, Department of Pathology, Nashville, Tennessee, USAVanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USAVanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USAVanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USAVanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USAVanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USARare variants in TTN are the most common monogenic cause of early-onset atrial fibrillation and dilated cardiomyopathy. Whereas cardiac sarcoidosis is very underdiagnosed, a common presentation can be ventricular arrhythmias. This report presents a patient with a likely pathogenic TTN variant and cardiac sarcoidosis. (Level of Difficulty: Intermediate.)http://www.sciencedirect.com/science/article/pii/S2666084923001833atrial fibrillationcardiomyopathygenetic disordersimagingventricular tachycardia |
| spellingShingle | Zain M. Virk, MD T. Lee Richardson, Jr., MD Joseph F. Nowatzke, MD Asad Ullah, MD Dawn M. Pedrotty, MD M. Benjamin Shoemaker, MD, MSCI Arvindh Kanagasundram, MD Dan M. Roden, MD William G. Stevenson, MD Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia JACC: Case Reports atrial fibrillation cardiomyopathy genetic disorders imaging ventricular tachycardia |
| title | Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia |
| title_full | Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia |
| title_fullStr | Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia |
| title_full_unstemmed | Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia |
| title_short | Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia |
| title_sort | cardiac sarcoidosis and a likely pathogenic ttn variant in a patient presenting with ventricular tachycardia |
| topic | atrial fibrillation cardiomyopathy genetic disorders imaging ventricular tachycardia |
| url | http://www.sciencedirect.com/science/article/pii/S2666084923001833 |
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