Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in healthy and type 2 diabetic rats

Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in healthy and type 2 diabetic rats

Objective: This study aimed to investigate effect of antidiabetic herb Astragali Radix (AR) on pharmacokinetic behavior of dapagliflozin (DAPA) in healthy rats and type 2 diabetes mellitus (T2DM) rats.Methods: The T2DM rats were induced by high-fat diet (HFD) and intraperitoneal injection of strepto...

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Bibliographic Details
Main Authors:	Wandi Du, Jiarong Hu, Jingru Liang, Xiaolei Yang, Boyu Fang, Guo Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Series:	Frontiers in Pharmacology
Subjects:	dapagliflozin Astragali radix Astragali radix extract type 2 diabetes mellitus pharmacokinetics UPLC-MS/MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1214658/full

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