Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients.
Background: The purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid (MPA) in Iranian kidney transplant patients. Methods: Plasma MPA concentration of mycophenolate mofetile (MMF) 1 gram two times a day was measured in 21 Iranian kidney transplant recipients...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Research Center for Rational Use of Drugs (RCRUD)
2015-10-01
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| Series: | Journal of Pharmaceutical Care |
| Subjects: | |
| Online Access: | https://jpc.tums.ac.ir/index.php/jpc/article/view/4 |
| _version_ | 1811265439579242496 |
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| author | Kheirollah Gholami Mohammadreza Rouini Niayesh Mohebbi Iman Karimzadeh Mehdi Ahadi-barzoki Mahboob Lessan-pezeshki Saeed Rezaee |
| author_facet | Kheirollah Gholami Mohammadreza Rouini Niayesh Mohebbi Iman Karimzadeh Mehdi Ahadi-barzoki Mahboob Lessan-pezeshki Saeed Rezaee |
| author_sort | Kheirollah Gholami |
| collection | DOAJ |
| description | Background: The purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid (MPA) in Iranian kidney transplant patients.
Methods: Plasma MPA concentration of mycophenolate mofetile (MMF) 1 gram two times a day was measured in 21 Iranian kidney transplant recipients receiving treatment. Patients who entered the study had been transplanted for more than 3 months and their drug level was supposed to be at steady state. MMF concentration was measured with High- Performance Liquid Chromatography (HPLC).
Results: The plasma MPA concentration-time curve was characterized by an early sharp peak at about 1 hour postdose. The mean Area Under Curve (AUC), Cmax and Tmax were 47.0±18.3 µg.h/ml, 18.6±8.5 µg/ml and 1.0±0.5 hours respectively.
Conclusion: The plasma MPA concentration-time curve pattern of Iranian patients was similar and consistent with previously reported profiles in other populations taking the same dose. |
| first_indexed | 2024-04-12T20:24:09Z |
| format | Article |
| id | doaj.art-7bf10d59cd5d43ce8c433d41261879ce |
| institution | Directory Open Access Journal |
| issn | 2322-4630 2322-4509 |
| language | English |
| last_indexed | 2024-04-12T20:24:09Z |
| publishDate | 2015-10-01 |
| publisher | Research Center for Rational Use of Drugs (RCRUD) |
| record_format | Article |
| series | Journal of Pharmaceutical Care |
| spelling | doaj.art-7bf10d59cd5d43ce8c433d41261879ce2022-12-22T03:17:55ZengResearch Center for Rational Use of Drugs (RCRUD)Journal of Pharmaceutical Care2322-46302322-45092015-10-0111Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients.Kheirollah Gholami0Mohammadreza Rouini1Niayesh Mohebbi2Iman Karimzadeh3Mehdi Ahadi-barzoki4Mahboob Lessan-pezeshki5Saeed Rezaee6Clinical Pharmacy Department, Faculty of Pharmacy and Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranClinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranClinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranFood and Drug Administration, Ministry of Health, Tehran, IranDepartment of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutics, Faculty of Pharmacy, Ahvaz University of Medical Sciences, Ahvaz, IranBackground: The purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid (MPA) in Iranian kidney transplant patients. Methods: Plasma MPA concentration of mycophenolate mofetile (MMF) 1 gram two times a day was measured in 21 Iranian kidney transplant recipients receiving treatment. Patients who entered the study had been transplanted for more than 3 months and their drug level was supposed to be at steady state. MMF concentration was measured with High- Performance Liquid Chromatography (HPLC). Results: The plasma MPA concentration-time curve was characterized by an early sharp peak at about 1 hour postdose. The mean Area Under Curve (AUC), Cmax and Tmax were 47.0±18.3 µg.h/ml, 18.6±8.5 µg/ml and 1.0±0.5 hours respectively. Conclusion: The plasma MPA concentration-time curve pattern of Iranian patients was similar and consistent with previously reported profiles in other populations taking the same dose.https://jpc.tums.ac.ir/index.php/jpc/article/view/4Mycophenolate mofetilMycophenolic acidPharmacokineticsArea Under CurveKidney transplantation |
| spellingShingle | Kheirollah Gholami Mohammadreza Rouini Niayesh Mohebbi Iman Karimzadeh Mehdi Ahadi-barzoki Mahboob Lessan-pezeshki Saeed Rezaee Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients. Journal of Pharmaceutical Care Mycophenolate mofetil Mycophenolic acid Pharmacokinetics Area Under Curve Kidney transplantation |
| title | Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients. |
| title_full | Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients. |
| title_fullStr | Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients. |
| title_full_unstemmed | Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients. |
| title_short | Pharmacokinetic study of mycophenolic acid in Iranian kidney transplant patients. |
| title_sort | pharmacokinetic study of mycophenolic acid in iranian kidney transplant patients |
| topic | Mycophenolate mofetil Mycophenolic acid Pharmacokinetics Area Under Curve Kidney transplantation |
| url | https://jpc.tums.ac.ir/index.php/jpc/article/view/4 |
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