MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells

MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells

The MCM2–7 hetero-hexamer is the replicative DNA helicase that plays a central role in eukaryotic DNA replication. In proliferating cells, the expression level of the MCM2–7 hexamer is kept high, which safeguards the integrity of the genome. However, how the MCM2–7 hexamer is assembled in living cel...

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Bibliographic Details
Main Authors: Yuichiro Saito, Venny Santosa, Kei-ichiro Ishiguro, Masato T Kanemaki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
DNA replication
genome instability
MCM2–7
MCMBP
protein complex assembly
Online Access:https://elifesciences.org/articles/77393

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