Radical SAM-dependent ether crosslink in daropeptide biosynthesis
Darobactin is a ribosomally synthesized and post-translationally modified peptide featuring a unique scaffold and potent activity against Gram-negative bacteria. Here, the authors identify darobactin synthase DarE as responsible for the bicyclic scaffold formation and propose the name daropeptide fo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30084-2 |
| _version_ | 1811289169159258112 |
|---|---|
| author | Sijia Guo Shu Wang Suze Ma Zixin Deng Wei Ding Qi Zhang |
| author_facet | Sijia Guo Shu Wang Suze Ma Zixin Deng Wei Ding Qi Zhang |
| author_sort | Sijia Guo |
| collection | DOAJ |
| description | Darobactin is a ribosomally synthesized and post-translationally modified peptide featuring a unique scaffold and potent activity against Gram-negative bacteria. Here, the authors identify darobactin synthase DarE as responsible for the bicyclic scaffold formation and propose the name daropeptide for this growing class of enzymes. |
| first_indexed | 2024-04-13T03:50:07Z |
| format | Article |
| id | doaj.art-7bf31149dabd41ef9f0b8e4d6d2e7661 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T03:50:07Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7bf31149dabd41ef9f0b8e4d6d2e76612022-12-22T03:03:50ZengNature PortfolioNature Communications2041-17232022-04-011311910.1038/s41467-022-30084-2Radical SAM-dependent ether crosslink in daropeptide biosynthesisSijia Guo0Shu Wang1Suze Ma2Zixin Deng3Wei Ding4Qi Zhang5State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong UniversityDepartment of Chemistry, Fudan UniversityDepartment of Chemistry, Fudan UniversityState Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong UniversityState Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong UniversityDepartment of Chemistry, Fudan UniversityDarobactin is a ribosomally synthesized and post-translationally modified peptide featuring a unique scaffold and potent activity against Gram-negative bacteria. Here, the authors identify darobactin synthase DarE as responsible for the bicyclic scaffold formation and propose the name daropeptide for this growing class of enzymes.https://doi.org/10.1038/s41467-022-30084-2 |
| spellingShingle | Sijia Guo Shu Wang Suze Ma Zixin Deng Wei Ding Qi Zhang Radical SAM-dependent ether crosslink in daropeptide biosynthesis Nature Communications |
| title | Radical SAM-dependent ether crosslink in daropeptide biosynthesis |
| title_full | Radical SAM-dependent ether crosslink in daropeptide biosynthesis |
| title_fullStr | Radical SAM-dependent ether crosslink in daropeptide biosynthesis |
| title_full_unstemmed | Radical SAM-dependent ether crosslink in daropeptide biosynthesis |
| title_short | Radical SAM-dependent ether crosslink in daropeptide biosynthesis |
| title_sort | radical sam dependent ether crosslink in daropeptide biosynthesis |
| url | https://doi.org/10.1038/s41467-022-30084-2 |
| work_keys_str_mv | AT sijiaguo radicalsamdependentethercrosslinkindaropeptidebiosynthesis AT shuwang radicalsamdependentethercrosslinkindaropeptidebiosynthesis AT suzema radicalsamdependentethercrosslinkindaropeptidebiosynthesis AT zixindeng radicalsamdependentethercrosslinkindaropeptidebiosynthesis AT weiding radicalsamdependentethercrosslinkindaropeptidebiosynthesis AT qizhang radicalsamdependentethercrosslinkindaropeptidebiosynthesis |