Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer Cells
Two new organic-inorganic hybrid compounds containing dicarboxylic pyridine acids have been obtained and characterized. Both compounds are potassium oxidodiperoxidomolybdates with 2,6-dicarboxylicpyridine acid or 3,5-dicarboxylicpyridine acid moieties, respectively. The chemical formula for the firs...
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| author | Adrianna Sławińska Małgorzata Tyszka-Czochara Paweł Serda Marcin Oszajca Małgorzata Ruggiero-Mikołajczyk Katarzyna Pamin Robert Karcz Wiesław Łasocha |
| author_facet | Adrianna Sławińska Małgorzata Tyszka-Czochara Paweł Serda Marcin Oszajca Małgorzata Ruggiero-Mikołajczyk Katarzyna Pamin Robert Karcz Wiesław Łasocha |
| author_sort | Adrianna Sławińska |
| collection | DOAJ |
| description | Two new organic-inorganic hybrid compounds containing dicarboxylic pyridine acids have been obtained and characterized. Both compounds are potassium oxidodiperoxidomolybdates with 2,6-dicarboxylicpyridine acid or 3,5-dicarboxylicpyridine acid moieties, respectively. The chemical formula for the first one is C<sub>14</sub>H<sub>7</sub>K<sub>3</sub>Mo<sub>2</sub>N<sub>2</sub>O<sub>18</sub> denoted as <b>K26dcpa</b>, the second C<sub>7</sub>H<sub>4</sub>K<sub>1</sub>Mo<sub>1</sub>N<sub>1</sub>O<sub>11.5</sub>—<b>K35dcpa</b>. Their crystal structures were determined using single crystal (<b>K26dcpa</b>) or XRPD—X-ray powder diffraction techniques (<b>K35dcpa</b>). The purity of the compounds was confirmed by elemental analysis. Their thermal stability was determined with the use of non-ambient XRPD. In addition, they were examined by IR spectroscopy methods and catalytic activity studies were performed for them. Catalytic tests in the Baeyer–Villiger reaction and biological activity have been performed for eight compounds: <b>K26dcpa</b>, <b>K35dcpa</b>, and six peroxidomolybdates previously obtained by our group. The anti-proliferative activity of peroxidomolybdenum compounds after 24 h of incubation was studied in vitro against three selected human tumor cell lines (SW620, LoVo, HEP G2) and normal human cells (fibroblasts). The data were expressed as IC<sub>50</sub> values. The structure of the investigated oxodiperoxomolybdenum compounds was shown to have influence on the biological activity and catalytic properties. It has been shown that the newly-obtained compound, <b>K35dcpa</b>, is a very efficient catalyst in the Baeyer–Villiger reaction. The best biological activity results were obtained for <i>Na-picO</i> (previously obtained by us), which is a very effective anti-cancer agent towards SW 620 <i>colorectal adenocarcinoma</i> cells. |
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| spelling | doaj.art-7bf350f6c8364ffabdded4306271550a2023-11-23T11:50:21ZengMDPI AGMaterials1996-19442021-12-0115124110.3390/ma15010241Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer CellsAdrianna Sławińska0Małgorzata Tyszka-Czochara1Paweł Serda2Marcin Oszajca3Małgorzata Ruggiero-Mikołajczyk4Katarzyna Pamin5Robert Karcz6Wiesław Łasocha7Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Krakow, PolandFaculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, PolandFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, PolandFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, PolandJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Krakow, PolandJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Krakow, PolandJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Krakow, PolandJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Krakow, PolandTwo new organic-inorganic hybrid compounds containing dicarboxylic pyridine acids have been obtained and characterized. Both compounds are potassium oxidodiperoxidomolybdates with 2,6-dicarboxylicpyridine acid or 3,5-dicarboxylicpyridine acid moieties, respectively. The chemical formula for the first one is C<sub>14</sub>H<sub>7</sub>K<sub>3</sub>Mo<sub>2</sub>N<sub>2</sub>O<sub>18</sub> denoted as <b>K26dcpa</b>, the second C<sub>7</sub>H<sub>4</sub>K<sub>1</sub>Mo<sub>1</sub>N<sub>1</sub>O<sub>11.5</sub>—<b>K35dcpa</b>. Their crystal structures were determined using single crystal (<b>K26dcpa</b>) or XRPD—X-ray powder diffraction techniques (<b>K35dcpa</b>). The purity of the compounds was confirmed by elemental analysis. Their thermal stability was determined with the use of non-ambient XRPD. In addition, they were examined by IR spectroscopy methods and catalytic activity studies were performed for them. Catalytic tests in the Baeyer–Villiger reaction and biological activity have been performed for eight compounds: <b>K26dcpa</b>, <b>K35dcpa</b>, and six peroxidomolybdates previously obtained by our group. The anti-proliferative activity of peroxidomolybdenum compounds after 24 h of incubation was studied in vitro against three selected human tumor cell lines (SW620, LoVo, HEP G2) and normal human cells (fibroblasts). The data were expressed as IC<sub>50</sub> values. The structure of the investigated oxodiperoxomolybdenum compounds was shown to have influence on the biological activity and catalytic properties. It has been shown that the newly-obtained compound, <b>K35dcpa</b>, is a very efficient catalyst in the Baeyer–Villiger reaction. The best biological activity results were obtained for <i>Na-picO</i> (previously obtained by us), which is a very effective anti-cancer agent towards SW 620 <i>colorectal adenocarcinoma</i> cells.https://www.mdpi.com/1996-1944/15/1/241peroxidomolybdatespolyoxocompoundshybrid materialX-ray based crystal structure analysisthermal decompositioncyclooctane oxidation |
| spellingShingle | Adrianna Sławińska Małgorzata Tyszka-Czochara Paweł Serda Marcin Oszajca Małgorzata Ruggiero-Mikołajczyk Katarzyna Pamin Robert Karcz Wiesław Łasocha Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer Cells Materials peroxidomolybdates polyoxocompounds hybrid material X-ray based crystal structure analysis thermal decomposition cyclooctane oxidation |
| title | Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer Cells |
| title_full | Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer Cells |
| title_fullStr | Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer Cells |
| title_full_unstemmed | Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer Cells |
| title_short | Newly-Obtained Two Organic-Inorganic Hybrid Compounds Based on Potassium Peroxidomolybdate and Dicarboxypyridinic Acid: Structure Determination, Catalytic Properties, and Cytotoxic Effects of Eight Peroxidomolybdates in Colon and Hepatic Cancer Cells |
| title_sort | newly obtained two organic inorganic hybrid compounds based on potassium peroxidomolybdate and dicarboxypyridinic acid structure determination catalytic properties and cytotoxic effects of eight peroxidomolybdates in colon and hepatic cancer cells |
| topic | peroxidomolybdates polyoxocompounds hybrid material X-ray based crystal structure analysis thermal decomposition cyclooctane oxidation |
| url | https://www.mdpi.com/1996-1944/15/1/241 |
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