Sargahydroquinoic Acid Suppresses Hyperpigmentation by cAMP and ERK1/2-Mediated Downregulation of MITF in α-MSH-Stimulated B16F10 Cells

Sargahydroquinoic Acid Suppresses Hyperpigmentation by cAMP and ERK1/2-Mediated Downregulation of MITF in α-MSH-Stimulated B16F10 Cells

Hyperpigmentation diseases of the skin require topical treatment with depigmenting agents. We investigated the hypopigmented mechanisms of sargahydroquinoic acid (SHQA) in alpha-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 cells. SHQA reduced cellular tyrosinase (TYR) activity and melani...

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Bibliographic Details
Main Authors: Mohammed Shariful Azam, Jae-Il Kim, Chang Geun Choi, Jinkyung Choi, Bonggi Lee, Hyeung-Rak Kim
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Foods
Subjects:
cAMP
ERK
hyperpigmentation
melanin
MITF
sargahydroquinoic acid
Online Access:https://www.mdpi.com/2304-8158/10/10/2254

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