Polyvinyl alcohol/gum Arabic hydrogel preparation and cytotoxicity for wound healing improvement
The application of pure polyvinyl alcohol (PVA) hydrogel as wound dressing faces many restrictions due to its insufficient elasticity, stiff membrane, and very limited hydrophilicity. These drawbacks can be limited through cross-linking with other natural biopolymers such as gum Arabic (GA). PVA hyd...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-07-01
|
| Series: | e-Polymers |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/epoly-2022-0052 |
| _version_ | 1811203718579748864 |
|---|---|
| author | Elblbesy Mohamed A. Hanafy Taha A. Shawki Mamdouh M. |
| author_facet | Elblbesy Mohamed A. Hanafy Taha A. Shawki Mamdouh M. |
| author_sort | Elblbesy Mohamed A. |
| collection | DOAJ |
| description | The application of pure polyvinyl alcohol (PVA) hydrogel as wound dressing faces many restrictions due to its insufficient elasticity, stiff membrane, and very limited hydrophilicity. These drawbacks can be limited through cross-linking with other natural biopolymers such as gum Arabic (GA). PVA hydrogels blended with six different GA concentrations were prepared. The characterization of these hydrogels was performed by Fourier transform infrared spectrophotometer, X-ray diffraction, and scanning electron microscope. The swelling ratio (% SR) percentage has been calculated. The possible cytotoxicity was determined using a sulforhodamine B assay. Wound healing test was performed on human skin fibroblast cells. Our results indicated that by increasing GA concentration in PVA hydrogel, the % SR increases and the cytotoxicity effect decreases. The results indicate also a significant gradual decrease in the wound area with time as the GA concentration increases in the PVA hydrogel. Therefore, GA improves the biological applications of PVA hydrogel. |
| first_indexed | 2024-04-12T03:00:48Z |
| format | Article |
| id | doaj.art-7bf52074baef4656a0b36934e0fbce30 |
| institution | Directory Open Access Journal |
| issn | 1618-7229 |
| language | English |
| last_indexed | 2024-04-12T03:00:48Z |
| publishDate | 2022-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | e-Polymers |
| spelling | doaj.art-7bf52074baef4656a0b36934e0fbce302022-12-22T03:50:41ZengDe Gruytere-Polymers1618-72292022-07-0122156657610.1515/epoly-2022-0052Polyvinyl alcohol/gum Arabic hydrogel preparation and cytotoxicity for wound healing improvementElblbesy Mohamed A.0Hanafy Taha A.1Shawki Mamdouh M.2Medical Biophysics Department, Medical Research Institute, Alexandria University, Alexandria city, EgyptDepartment of Physics and Nanotechnology Research Laboratory, Faculty of Science, University of Tabuk, Tabuk, Saudi ArabiaMedical Biophysics Department, Medical Research Institute, Alexandria University, Alexandria city, EgyptThe application of pure polyvinyl alcohol (PVA) hydrogel as wound dressing faces many restrictions due to its insufficient elasticity, stiff membrane, and very limited hydrophilicity. These drawbacks can be limited through cross-linking with other natural biopolymers such as gum Arabic (GA). PVA hydrogels blended with six different GA concentrations were prepared. The characterization of these hydrogels was performed by Fourier transform infrared spectrophotometer, X-ray diffraction, and scanning electron microscope. The swelling ratio (% SR) percentage has been calculated. The possible cytotoxicity was determined using a sulforhodamine B assay. Wound healing test was performed on human skin fibroblast cells. Our results indicated that by increasing GA concentration in PVA hydrogel, the % SR increases and the cytotoxicity effect decreases. The results indicate also a significant gradual decrease in the wound area with time as the GA concentration increases in the PVA hydrogel. Therefore, GA improves the biological applications of PVA hydrogel.https://doi.org/10.1515/epoly-2022-0052polyvinyl alcoholgum arabichydrogelcytotoxicitywound healing |
| spellingShingle | Elblbesy Mohamed A. Hanafy Taha A. Shawki Mamdouh M. Polyvinyl alcohol/gum Arabic hydrogel preparation and cytotoxicity for wound healing improvement e-Polymers polyvinyl alcohol gum arabic hydrogel cytotoxicity wound healing |
| title | Polyvinyl alcohol/gum Arabic hydrogel preparation and cytotoxicity for wound healing improvement |
| title_full | Polyvinyl alcohol/gum Arabic hydrogel preparation and cytotoxicity for wound healing improvement |
| title_fullStr | Polyvinyl alcohol/gum Arabic hydrogel preparation and cytotoxicity for wound healing improvement |
| title_full_unstemmed | Polyvinyl alcohol/gum Arabic hydrogel preparation and cytotoxicity for wound healing improvement |
| title_short | Polyvinyl alcohol/gum Arabic hydrogel preparation and cytotoxicity for wound healing improvement |
| title_sort | polyvinyl alcohol gum arabic hydrogel preparation and cytotoxicity for wound healing improvement |
| topic | polyvinyl alcohol gum arabic hydrogel cytotoxicity wound healing |
| url | https://doi.org/10.1515/epoly-2022-0052 |
| work_keys_str_mv | AT elblbesymohameda polyvinylalcoholgumarabichydrogelpreparationandcytotoxicityforwoundhealingimprovement AT hanafytahaa polyvinylalcoholgumarabichydrogelpreparationandcytotoxicityforwoundhealingimprovement AT shawkimamdouhm polyvinylalcoholgumarabichydrogelpreparationandcytotoxicityforwoundhealingimprovement |