Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i>
Aberrant centrosome activities in mutants of <i>Dictyostelium discoideum</i> result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by el...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/9/2240 |
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| author | Mary Ecke Jana Prassler Günther Gerisch |
| author_facet | Mary Ecke Jana Prassler Günther Gerisch |
| author_sort | Mary Ecke |
| collection | DOAJ |
| description | Aberrant centrosome activities in mutants of <i>Dictyostelium discoideum</i> result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed. |
| first_indexed | 2024-03-10T07:49:24Z |
| format | Article |
| id | doaj.art-7bf62f72878a40638a6c1cb474033fce |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:49:24Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7bf62f72878a40638a6c1cb474033fce2023-11-22T12:23:02ZengMDPI AGCells2073-44092021-08-01109224010.3390/cells10092240Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i>Mary Ecke0Jana Prassler1Günther Gerisch2Cell Dynamics Group, Max Planck Institute of Biochemistry, am Klopferspitz 18, D-82152 Martinsried, GermanyCell Dynamics Group, Max Planck Institute of Biochemistry, am Klopferspitz 18, D-82152 Martinsried, GermanyCell Dynamics Group, Max Planck Institute of Biochemistry, am Klopferspitz 18, D-82152 Martinsried, GermanyAberrant centrosome activities in mutants of <i>Dictyostelium discoideum</i> result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed.https://www.mdpi.com/2073-4409/10/9/2240centrosomeschromosome segregation<i>Dictyostelium</i>genetic instabilitymitosismultinucleate cells |
| spellingShingle | Mary Ecke Jana Prassler Günther Gerisch Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i> Cells centrosomes chromosome segregation <i>Dictyostelium</i> genetic instability mitosis multinucleate cells |
| title | Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i> |
| title_full | Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i> |
| title_fullStr | Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i> |
| title_full_unstemmed | Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i> |
| title_short | Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i> |
| title_sort | genetic instability due to spindle anomalies visualized in mutants of i dictyostelium i |
| topic | centrosomes chromosome segregation <i>Dictyostelium</i> genetic instability mitosis multinucleate cells |
| url | https://www.mdpi.com/2073-4409/10/9/2240 |
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