Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i>

Genetic Instability Due to Spindle Anomalies Visualized in Mutants of <i>Dictyostelium</i>

Aberrant centrosome activities in mutants of <i>Dictyostelium discoideum</i> result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by el...

Full description

Bibliographic Details
Main Authors:	Mary Ecke, Jana Prassler, Günther Gerisch
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Cells
Subjects:	centrosomes chromosome segregation <i>Dictyostelium</i> genetic instability mitosis multinucleate cells
Online Access:	https://www.mdpi.com/2073-4409/10/9/2240

Similar Items

The <i>Dictyostelium</i> Centrosome
by: Ralph Gräf, et al.
Published: (2021-10-01)

CDK5RAP2 Is an Essential Scaffolding Protein of the Corona of the Dictyostelium Centrosome
by: Valentin Pitzen, et al.
Published: (2018-04-01)

Temporal Changes in Nuclear Envelope Permeability during Semi-Closed Mitosis in <i>Dictyostelium</i> Amoebae
by: Kristina Mitic, et al.
Published: (2023-05-01)

Partial Disassembly of the Nuclear Pore Complex Proteins during Semi-Closed Mitosis in <i>Dictyostelium discoideum</i>
by: Kristina Mitic, et al.
Published: (2022-01-01)

Rules of engagement: centrosome–nuclear connections in a closed mitotic system
by: Meredith Leo, et al.
Published: (2012-09-01)

The genomic stability regulator PTIP is required for proper chromosome segregation in mitosis
by: Fengxia Zhang, et al.
Published: (2022-09-01)

Transient defects of mitotic spindle geometry and chromosome segregation errors
by: Silkworth William T, et al.
Published: (2012-08-01)

A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability
by: Bernardo eOrr, et al.
Published: (2013-06-01)

Cep192, a Novel Missing Link between the Centrosomal Core and Corona in <i>Dictyostelium</i> Amoebae
by: Valentin Pitzen, et al.
Published: (2021-09-01)

Estrogens—Origin of Centrosome Defects in Human Cancer?
by: Miriam Bühler, et al.
Published: (2022-01-01)

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer
by: Marco R. Cosenza, et al.
Published: (2017-08-01)

Catastrophic chromosomal restructuring during genome elimination in plants
by: Ek Han Tan, et al.
Published: (2015-05-01)

Centrosome Positioning in Dictyostelium: Moving beyond Microtubule Tip Dynamics
by: Michael P. Koonce, et al.
Published: (2018-04-01)

Unilateral Cleavage Furrows in Multinucleate Cells
by: Julia Bindl, et al.
Published: (2020-06-01)

DNA Replication Stress and Chromosomal Instability: Dangerous Liaisons
by: Therese Wilhelm, et al.
Published: (2020-06-01)

Proteins of the Nucleolus of <i>Dictyostelium discoideum</i>: Nucleolar Compartmentalization, Targeting Sequences, Protein Translocations and Binding Partners
by: Danton H. O’Day
Published: (2019-02-01)

Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble
by: Tsz Yin Lau, et al.
Published: (2023-02-01)

Aurora kinase-C-T191D is constitutively active mutant
by: Khan Jabbar, et al.
Published: (2012-03-01)

Mitotic Acetylation of Microtubules Promotes Centrosomal <i>PLK1</i> Recruitment and Is Required to Maintain Bipolar Spindle Homeostasis
by: Sylvia Fenosoa Rasamizafy, et al.
Published: (2021-07-01)

Flow-driven instabilities during pattern formation of Dictyostelium discoideum
by: A Gholami, et al.
Published: (2015-01-01)

Nucleus-Cytoskeleton Crosstalk During Mitotic Entry
by: Margarida Dantas, et al.
Published: (2021-03-01)

Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRC
by: Richard F. Reschen, et al.
Published: (2012-03-01)

Bioenergetics of the <i>Dictyostelium</i> Kinesin-8 Motor Isoform
by: Michael P. Koonce, et al.
Published: (2020-04-01)

Axial contraction and short-range compaction of chromatin synergistically promote mitotic chromosome condensation
by: Tom Kruitwagen, et al.
Published: (2015-11-01)

Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in <i>Dictyostelium discoideum</i>
by: Sanjanie Fernando, et al.
Published: (2020-10-01)

<i>Dictyostelium</i> Cell Fixation: Two Simple Tricks
by: Michael Koonce, et al.
Published: (2020-07-01)

Fission yeast neddylation ligase Dcn1 facilitates cohesin cleavage and chromosome segregation at anaphase
by: Lan Lin, et al.
Published: (2017-06-01)

In Vivo Assembly of a <i>Dictyostelium</i> Lamin Mutant Induced by Light, Mechanical Stress, and pH
by: Marianne Grafe, et al.
Published: (2020-08-01)

Centrosome age regulates kinetochore–microtubule stability and biases chromosome mis-segregation
by: Ivana Gasic, et al.
Published: (2015-08-01)

A FRET-based study reveals site-specific regulation of spindle position checkpoint proteins at yeast centrosomes
by: Yuliya Gryaznova, et al.
Published: (2016-05-01)

Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells
by: Jennifer H. Toyoda, et al.
Published: (2023-12-01)

The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint
by: Babhrubahan Roy, et al.
Published: (2020-06-01)

Interactome and F-Actin Interaction Analysis of <i>Dictyostelium discoideum</i> Coronin A
by: Tohnyui Ndinyanka Fabrice, et al.
Published: (2020-02-01)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
by: Christy Hong, et al.
Published: (2019-10-01)

Chromosomal instability, aneuploidy, and cancer
by: Samuel F Bakhoum, et al.
Published: (2014-06-01)

Proteomic and Transcriptomic Profiling Identifies Early Developmentally Regulated Proteins in <i>Dictyostelium Discoideum</i>
by: Óscar González-Velasco, et al.
Published: (2019-10-01)

13 Plus 1: A 30-Year Perspective on Microtubule-Based Motility in <i>Dictyostelium</i>
by: Michael P. Koonce
Published: (2020-02-01)

Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80
by: David M Kern, et al.
Published: (2017-08-01)

Flow-driven two-dimensional waves in colonies of Dictyostelium discoideum
by: A Gholami, et al.
Published: (2015-01-01)

P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells
by: Tracy Vargo-Gogola, et al.
Published: (2012-04-01)