Exosomes in Colorectal Cancer: From Physiology to Clinical Applications
Exosomes are nanosized vesicles that have been found to be involved in many diseases. Exosomes can mediate communication between cells in a variety of ways. Certain types of mediators derived from cancer cells can play a crucial role in the development of this pathology, promoting tumor growth, inva...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4382 |
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| author | Stefan Titu Vlad Alexandru Gata Roxana Maria Decea Teodora Mocan Constantin Dina Alexandru Irimie Cosmin Ioan Lisencu |
| author_facet | Stefan Titu Vlad Alexandru Gata Roxana Maria Decea Teodora Mocan Constantin Dina Alexandru Irimie Cosmin Ioan Lisencu |
| author_sort | Stefan Titu |
| collection | DOAJ |
| description | Exosomes are nanosized vesicles that have been found to be involved in many diseases. Exosomes can mediate communication between cells in a variety of ways. Certain types of mediators derived from cancer cells can play a crucial role in the development of this pathology, promoting tumor growth, invasion, metastasis, angiogenesis, and immunomodulation. Exosomes in the bloodstream show promise as a future tool for detecting cancer at an early stage. The sensitivity and specificity of clinical exosome biomarkers need to be enhanced. Knowledge of exosomes is not only important for understanding the significance of cancer progression but also for providing clinicians with useful information for the diagnosis, treatment, and discovery of methods to prevent cancer from recurring. The widespread adoption of diagnostic tools based on exosomes may revolutionize cancer diagnosis and treatment. Tumor metastasis, chemoresistance, and immunity are all aided by exosomes. A potential new approach to cancer therapy involves preventing metastasis by inhibiting miRNA intracellular signaling and blocking the formation of pre-metastatic niches. For colorectal patients, exosomes represent a promising area of investigation for improving the diagnosis, treatment, and management. Reported data demonstrate that the serum expression level of certain exosomal miRNA is significantly higher in primary colorectal cancer patients. The present review discusses mechanisms and clinical implications of exosomes in colorectal cancer. |
| first_indexed | 2024-03-11T07:23:39Z |
| format | Article |
| id | doaj.art-7bf6b89f29e4459398d0f5fbf6aed277 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:23:39Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7bf6b89f29e4459398d0f5fbf6aed2772023-11-17T07:47:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245438210.3390/ijms24054382Exosomes in Colorectal Cancer: From Physiology to Clinical ApplicationsStefan Titu0Vlad Alexandru Gata1Roxana Maria Decea2Teodora Mocan3Constantin Dina4Alexandru Irimie5Cosmin Ioan Lisencu6Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaDepartment of Surgical Oncology, The Oncology Institute “Prof. Dr. Ion Chiricuta” Cluj-Napoca, 400015 Cluj-Napoca, RomaniaDepartment of Physiology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaFaculty of Medicine, Ovidius University, 900527 Constanta, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaDepartment of Surgical Oncology, The Oncology Institute “Prof. Dr. Ion Chiricuta” Cluj-Napoca, 400015 Cluj-Napoca, RomaniaExosomes are nanosized vesicles that have been found to be involved in many diseases. Exosomes can mediate communication between cells in a variety of ways. Certain types of mediators derived from cancer cells can play a crucial role in the development of this pathology, promoting tumor growth, invasion, metastasis, angiogenesis, and immunomodulation. Exosomes in the bloodstream show promise as a future tool for detecting cancer at an early stage. The sensitivity and specificity of clinical exosome biomarkers need to be enhanced. Knowledge of exosomes is not only important for understanding the significance of cancer progression but also for providing clinicians with useful information for the diagnosis, treatment, and discovery of methods to prevent cancer from recurring. The widespread adoption of diagnostic tools based on exosomes may revolutionize cancer diagnosis and treatment. Tumor metastasis, chemoresistance, and immunity are all aided by exosomes. A potential new approach to cancer therapy involves preventing metastasis by inhibiting miRNA intracellular signaling and blocking the formation of pre-metastatic niches. For colorectal patients, exosomes represent a promising area of investigation for improving the diagnosis, treatment, and management. Reported data demonstrate that the serum expression level of certain exosomal miRNA is significantly higher in primary colorectal cancer patients. The present review discusses mechanisms and clinical implications of exosomes in colorectal cancer.https://www.mdpi.com/1422-0067/24/5/4382exosomecancercolorectal cancerexosomal miRNAlncRNA |
| spellingShingle | Stefan Titu Vlad Alexandru Gata Roxana Maria Decea Teodora Mocan Constantin Dina Alexandru Irimie Cosmin Ioan Lisencu Exosomes in Colorectal Cancer: From Physiology to Clinical Applications International Journal of Molecular Sciences exosome cancer colorectal cancer exosomal miRNA lncRNA |
| title | Exosomes in Colorectal Cancer: From Physiology to Clinical Applications |
| title_full | Exosomes in Colorectal Cancer: From Physiology to Clinical Applications |
| title_fullStr | Exosomes in Colorectal Cancer: From Physiology to Clinical Applications |
| title_full_unstemmed | Exosomes in Colorectal Cancer: From Physiology to Clinical Applications |
| title_short | Exosomes in Colorectal Cancer: From Physiology to Clinical Applications |
| title_sort | exosomes in colorectal cancer from physiology to clinical applications |
| topic | exosome cancer colorectal cancer exosomal miRNA lncRNA |
| url | https://www.mdpi.com/1422-0067/24/5/4382 |
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