Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest Story
The story of the discovery of hepatitis E originated in the late 1970s with my extreme belief that there was a hidden saga in the relationship between jaundice and pregnancy in developing countries and the opportunity for a massive epidemic of viral hepatitis, which hit the Gulmarg Kashmir region in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/8/1745 |
| _version_ | 1827728482263629824 |
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| author | Mohammad Sultan Khuroo |
| author_facet | Mohammad Sultan Khuroo |
| author_sort | Mohammad Sultan Khuroo |
| collection | DOAJ |
| description | The story of the discovery of hepatitis E originated in the late 1970s with my extreme belief that there was a hidden saga in the relationship between jaundice and pregnancy in developing countries and the opportunity for a massive epidemic of viral hepatitis, which hit the Gulmarg Kashmir region in November 1978. Based on data collected from a door-to-door survey, the existence of a new disease, epidemic non-A, non-B hepatitis, caused by a hitherto unknown hepatitis virus, was announced. This news was received by the world community with hype and skepticism. In the early 1980s, the world watched in awe as an extreme example of human self-experimentation led to the identification of VLP. In 1990, a cDNA clone from the virus responsible for epidemic non-A, non-B hepatitis was isolated. Over the years, we traversed three eras of ambiguity, hope, and hype of hepatitis E research and conducted several seminal studies to understand the biology of HEV and manifestations of hepatitis E. Many milestones have been reached on the long and winding road of hepatitis E research to understand the structure, biology, and diversity of the agent, changing the behavior of the pathogen in developed countries, and the discovery of a highly effective vaccine. |
| first_indexed | 2024-03-10T23:30:45Z |
| format | Article |
| id | doaj.art-7bf7ae5ce32147f9a079c43ea078e992 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T23:30:45Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-7bf7ae5ce32147f9a079c43ea078e9922023-11-19T03:21:15ZengMDPI AGViruses1999-49152023-08-01158174510.3390/v15081745Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest StoryMohammad Sultan Khuroo0Digestive Diseases Centre, Dr. Khuroo’s Medical Clinic, Srinagar, Jammu & Kashmir 190010, IndiaThe story of the discovery of hepatitis E originated in the late 1970s with my extreme belief that there was a hidden saga in the relationship between jaundice and pregnancy in developing countries and the opportunity for a massive epidemic of viral hepatitis, which hit the Gulmarg Kashmir region in November 1978. Based on data collected from a door-to-door survey, the existence of a new disease, epidemic non-A, non-B hepatitis, caused by a hitherto unknown hepatitis virus, was announced. This news was received by the world community with hype and skepticism. In the early 1980s, the world watched in awe as an extreme example of human self-experimentation led to the identification of VLP. In 1990, a cDNA clone from the virus responsible for epidemic non-A, non-B hepatitis was isolated. Over the years, we traversed three eras of ambiguity, hope, and hype of hepatitis E research and conducted several seminal studies to understand the biology of HEV and manifestations of hepatitis E. Many milestones have been reached on the long and winding road of hepatitis E research to understand the structure, biology, and diversity of the agent, changing the behavior of the pathogen in developed countries, and the discovery of a highly effective vaccine.https://www.mdpi.com/1999-4915/15/8/1745discoveryepidemicsporadicnon-A, non-B hepatitishepatitis E virushepatitis E |
| spellingShingle | Mohammad Sultan Khuroo Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest Story Viruses discovery epidemic sporadic non-A, non-B hepatitis hepatitis E virus hepatitis E |
| title | Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest Story |
| title_full | Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest Story |
| title_fullStr | Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest Story |
| title_full_unstemmed | Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest Story |
| title_short | Discovery of Hepatitis E and Its Impact on Global Health: A Journey of 44 Years about an Incredible Human-Interest Story |
| title_sort | discovery of hepatitis e and its impact on global health a journey of 44 years about an incredible human interest story |
| topic | discovery epidemic sporadic non-A, non-B hepatitis hepatitis E virus hepatitis E |
| url | https://www.mdpi.com/1999-4915/15/8/1745 |
| work_keys_str_mv | AT mohammadsultankhuroo discoveryofhepatitiseanditsimpactonglobalhealthajourneyof44yearsaboutanincrediblehumanintereststory |