A study to assess serum and tissue levels of sialic acid and hexosamine in keloids
Background: A keloid is an abnormal proliferation of scar tissue that forms at the site of cutaneous injury. The major component of scar tissue is the fibrous protein collagen, which is a glycoprotein. Sialic acid is a charged sugar that plays a key structural role in glycoprotein biosynthesis. Obj...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | MRIMS Journal of Health Sciences |
| Subjects: | |
| Online Access: | http://www.mrimsjournal.com/article.asp?issn=2321-7006;year=2015;volume=3;issue=2;spage=134;epage=137;aulast=Menon;type=0 |
| Summary: | Background: A keloid is an abnormal proliferation of scar tissue that forms at the site of cutaneous injury. The major component of scar tissue is the fibrous protein collagen, which is a glycoprotein. Sialic acid is a charged sugar that plays a key structural role in glycoprotein biosynthesis.
Objectives: Estimation of serum hexosamine and sialic acid in subjects with recurrent keloid formation as well as in normal subjects for comparison and to evaluate the role of these complex proteins in keloid formation.
Methods: A total number of 30 cases diagnosed as keloid and 30 controls attending to OPD were involved in the present study. The blood and skin biopsy sample were collected for estimation of biochemical parameters hexosamine and sialic acid.
Result: Serum levels of hexosamine (101 +/- 19.15) and sialic acid (1.435 +/- 0.34) in keloid subjects are not elevated significantly as compared to normal subjects (Serum Hexosamine 95.73 +/- 23.09) (Sialic acid 1.483 +/- 0.40) but significant (p<0.0001) increase in the tissue levels of sialic acid (0.98+/- 0.108) and hexosamine (1.66 +/- 0.419)are observed in keloid subjects as compared to normal (Sialic acid 0.65+/- 0.059 hexosamine 0.6+/- 0.109).
Conclusion: There is a significant increase in the levels of sialic acid and hexosamine in keloid tissue due to excessive deposition of collagen and matrix. |
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| ISSN: | 2321-7006 2321-7294 |