Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities
Nerolidol (3,7,11-trimethyl-1,6,10-dodecatrien-3-ol) is a naturally occurring sesquiterpene alcohol that is present in various plants with a floral odor. It is synthesized as an intermediate in the production of (3E)-4,8-dimethy-1,3,7-nonatriene (DMNT), a herbivore-induced volatile that protects pla...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/21/5/529 |
| _version_ | 1818672955022901248 |
|---|---|
| author | Weng-Keong Chan Loh Teng-Hern Tan Kok-Gan Chan Learn-Han Lee Bey-Hing Goh |
| author_facet | Weng-Keong Chan Loh Teng-Hern Tan Kok-Gan Chan Learn-Han Lee Bey-Hing Goh |
| author_sort | Weng-Keong Chan |
| collection | DOAJ |
| description | Nerolidol (3,7,11-trimethyl-1,6,10-dodecatrien-3-ol) is a naturally occurring sesquiterpene alcohol that is present in various plants with a floral odor. It is synthesized as an intermediate in the production of (3E)-4,8-dimethy-1,3,7-nonatriene (DMNT), a herbivore-induced volatile that protects plants from herbivore damage. Chemically, nerolidol exists in two geometric isomers, a trans and a cis form. The usage of nerolidol is widespread across different industries. It has been widely used in cosmetics (e.g., shampoos and perfumes) and in non-cosmetic products (e.g., detergents and cleansers). In fact, U.S. Food and Drug Administration (FDA) has also permitted the use of nerolidol as a food flavoring agent. The fact that nerolidol is a common ingredient in many products has attracted researchers to explore more medicinal properties of nerolidol that may exert beneficial effect on human health. Therefore, the aim of this review is to compile and consolidate the data on the various pharmacological and biological activities displayed by nerolidol. Furthermore, this review also includes pharmacokinetic and toxicological studies of nerolidol. In summary, the various pharmacological and biological activities demonstrated in this review highlight the prospects of nerolidol as a promising chemical or drug candidate in the field of agriculture and medicine. |
| first_indexed | 2024-12-17T07:48:07Z |
| format | Article |
| id | doaj.art-7bf96867625040288afc5a1fce4c3725 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-17T07:48:07Z |
| publishDate | 2016-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7bf96867625040288afc5a1fce4c37252022-12-21T21:57:56ZengMDPI AGMolecules1420-30492016-04-0121552910.3390/molecules21050529molecules21050529Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological ActivitiesWeng-Keong Chan0Loh Teng-Hern Tan1Kok-Gan Chan2Learn-Han Lee3Bey-Hing Goh4School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, MalaysiaSchool of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, MalaysiaDivision of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MalaysiaSchool of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, MalaysiaSchool of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, MalaysiaNerolidol (3,7,11-trimethyl-1,6,10-dodecatrien-3-ol) is a naturally occurring sesquiterpene alcohol that is present in various plants with a floral odor. It is synthesized as an intermediate in the production of (3E)-4,8-dimethy-1,3,7-nonatriene (DMNT), a herbivore-induced volatile that protects plants from herbivore damage. Chemically, nerolidol exists in two geometric isomers, a trans and a cis form. The usage of nerolidol is widespread across different industries. It has been widely used in cosmetics (e.g., shampoos and perfumes) and in non-cosmetic products (e.g., detergents and cleansers). In fact, U.S. Food and Drug Administration (FDA) has also permitted the use of nerolidol as a food flavoring agent. The fact that nerolidol is a common ingredient in many products has attracted researchers to explore more medicinal properties of nerolidol that may exert beneficial effect on human health. Therefore, the aim of this review is to compile and consolidate the data on the various pharmacological and biological activities displayed by nerolidol. Furthermore, this review also includes pharmacokinetic and toxicological studies of nerolidol. In summary, the various pharmacological and biological activities demonstrated in this review highlight the prospects of nerolidol as a promising chemical or drug candidate in the field of agriculture and medicine.http://www.mdpi.com/1420-3049/21/5/529cis-nerolidoltrans-nerolidolsesquiterpeneessential oilpharmacological activities |
| spellingShingle | Weng-Keong Chan Loh Teng-Hern Tan Kok-Gan Chan Learn-Han Lee Bey-Hing Goh Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities Molecules cis-nerolidol trans-nerolidol sesquiterpene essential oil pharmacological activities |
| title | Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities |
| title_full | Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities |
| title_fullStr | Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities |
| title_full_unstemmed | Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities |
| title_short | Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities |
| title_sort | nerolidol a sesquiterpene alcohol with multi faceted pharmacological and biological activities |
| topic | cis-nerolidol trans-nerolidol sesquiterpene essential oil pharmacological activities |
| url | http://www.mdpi.com/1420-3049/21/5/529 |
| work_keys_str_mv | AT wengkeongchan nerolidolasesquiterpenealcoholwithmultifacetedpharmacologicalandbiologicalactivities AT lohtengherntan nerolidolasesquiterpenealcoholwithmultifacetedpharmacologicalandbiologicalactivities AT kokganchan nerolidolasesquiterpenealcoholwithmultifacetedpharmacologicalandbiologicalactivities AT learnhanlee nerolidolasesquiterpenealcoholwithmultifacetedpharmacologicalandbiologicalactivities AT beyhinggoh nerolidolasesquiterpenealcoholwithmultifacetedpharmacologicalandbiologicalactivities |