UBASH3A Interacts with PTPN22 to Regulate <i>IL2</i> Expression and Risk for Type 1 Diabetes

UBASH3A Interacts with PTPN22 to Regulate <i>IL2</i> Expression and Risk for Type 1 Diabetes

UBASH3A is a negative regulator of T cell activation and IL-2 production and plays key roles in autoimmunity. Although previous studies revealed the individual effects of UBASH3A on risk for type 1 diabetes (T1D; a common autoimmune disease), the relationship of UBASH3A with other T1D risk factors r...

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Bibliographic Details
Main Authors: Jeremy R. B. Newman, Patrick Concannon, Yan Ge
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
UBASH3A
PTPN22
IL-2
type 1 diabetes
autoimmunity
rs11203203
Online Access:https://www.mdpi.com/1422-0067/24/10/8671

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