Red Blood Cell Distribution Width: A Novel Predictor of Mortality Following Amputation in Diabetic Foot
Category: Diabetes Introduction/Purpose: Red blood cell distribution width (RDW), reflects the degree of heterogeneity of erythrocyte volume, has been found to be a significant prognostic factor in various human disorders. Herein, we assessed the value of RDW as a prognostic factor in diabetic foot...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-01-01
|
| Series: | Foot & Ankle Orthopaedics |
| Online Access: | https://doi.org/10.1177/2473011421S00388 |
| _version_ | 1818332676365484032 |
|---|---|
| author | Jae Han Park MD Kwang Hwan Park MD, PhD Yeo Kwon Yoon MD Seung Hwan Han MD, PhD Jin Woo Lee MD, PhD |
| author_facet | Jae Han Park MD Kwang Hwan Park MD, PhD Yeo Kwon Yoon MD Seung Hwan Han MD, PhD Jin Woo Lee MD, PhD |
| author_sort | Jae Han Park MD |
| collection | DOAJ |
| description | Category: Diabetes Introduction/Purpose: Red blood cell distribution width (RDW), reflects the degree of heterogeneity of erythrocyte volume, has been found to be a significant prognostic factor in various human disorders. Herein, we assessed the value of RDW as a prognostic factor in diabetic foot amputation. Methods: Data of 415 patients with diabetic foot underwent amputation between January 2009 and January 2019 were analyzed retrospectively. After establishing a cut-off point of preoperative RDW for all-cause mortality, Cox proportional hazard model for mortality and logistic regression analysis for length of hospital stay more than 1 month were performed with other variable Results: RDW >14.5% was a significant risk factor for mortality (hazard ratio, 2.55; 95% confidence interval [CI], 1.55 to 4.19) on multivariable-adjusted regression analysis. Other significant factors associated with mortality were age and kidney disease. High RDW was also associated with longer hospitalization over 30 days (odds ratio, 2.17; 95% CI, 1.29 -3.66). Conclusion: High preoperative RDW over 14.5% is an independent prognostic factor with increased mortality and longer hospitalization, implying that RDW may be a simple and inexpensive laboratory parameter for risk stratification in diabetic foot amputation. |
| first_indexed | 2024-12-13T13:39:32Z |
| format | Article |
| id | doaj.art-7bffaecac41a4ed486307051458a1f64 |
| institution | Directory Open Access Journal |
| issn | 2473-0114 |
| language | English |
| last_indexed | 2024-12-13T13:39:32Z |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Foot & Ankle Orthopaedics |
| spelling | doaj.art-7bffaecac41a4ed486307051458a1f642022-12-21T23:43:38ZengSAGE PublishingFoot & Ankle Orthopaedics2473-01142022-01-01710.1177/2473011421S00388Red Blood Cell Distribution Width: A Novel Predictor of Mortality Following Amputation in Diabetic FootJae Han Park MDKwang Hwan Park MD, PhDYeo Kwon Yoon MDSeung Hwan Han MD, PhDJin Woo Lee MD, PhDCategory: Diabetes Introduction/Purpose: Red blood cell distribution width (RDW), reflects the degree of heterogeneity of erythrocyte volume, has been found to be a significant prognostic factor in various human disorders. Herein, we assessed the value of RDW as a prognostic factor in diabetic foot amputation. Methods: Data of 415 patients with diabetic foot underwent amputation between January 2009 and January 2019 were analyzed retrospectively. After establishing a cut-off point of preoperative RDW for all-cause mortality, Cox proportional hazard model for mortality and logistic regression analysis for length of hospital stay more than 1 month were performed with other variable Results: RDW >14.5% was a significant risk factor for mortality (hazard ratio, 2.55; 95% confidence interval [CI], 1.55 to 4.19) on multivariable-adjusted regression analysis. Other significant factors associated with mortality were age and kidney disease. High RDW was also associated with longer hospitalization over 30 days (odds ratio, 2.17; 95% CI, 1.29 -3.66). Conclusion: High preoperative RDW over 14.5% is an independent prognostic factor with increased mortality and longer hospitalization, implying that RDW may be a simple and inexpensive laboratory parameter for risk stratification in diabetic foot amputation.https://doi.org/10.1177/2473011421S00388 |
| spellingShingle | Jae Han Park MD Kwang Hwan Park MD, PhD Yeo Kwon Yoon MD Seung Hwan Han MD, PhD Jin Woo Lee MD, PhD Red Blood Cell Distribution Width: A Novel Predictor of Mortality Following Amputation in Diabetic Foot Foot & Ankle Orthopaedics |
| title | Red Blood Cell Distribution Width: A Novel Predictor of Mortality Following Amputation in Diabetic Foot |
| title_full | Red Blood Cell Distribution Width: A Novel Predictor of Mortality Following Amputation in Diabetic Foot |
| title_fullStr | Red Blood Cell Distribution Width: A Novel Predictor of Mortality Following Amputation in Diabetic Foot |
| title_full_unstemmed | Red Blood Cell Distribution Width: A Novel Predictor of Mortality Following Amputation in Diabetic Foot |
| title_short | Red Blood Cell Distribution Width: A Novel Predictor of Mortality Following Amputation in Diabetic Foot |
| title_sort | red blood cell distribution width a novel predictor of mortality following amputation in diabetic foot |
| url | https://doi.org/10.1177/2473011421S00388 |
| work_keys_str_mv | AT jaehanparkmd redbloodcelldistributionwidthanovelpredictorofmortalityfollowingamputationindiabeticfoot AT kwanghwanparkmdphd redbloodcelldistributionwidthanovelpredictorofmortalityfollowingamputationindiabeticfoot AT yeokwonyoonmd redbloodcelldistributionwidthanovelpredictorofmortalityfollowingamputationindiabeticfoot AT seunghwanhanmdphd redbloodcelldistributionwidthanovelpredictorofmortalityfollowingamputationindiabeticfoot AT jinwooleemdphd redbloodcelldistributionwidthanovelpredictorofmortalityfollowingamputationindiabeticfoot |